Biomaterial Database

Simultaneous upgrading reaction and erythema nodosum leprosum in a patient with lepromatous leprosy. 1988

C K Job, and R R Jacobson, and R C Hastings

Pathology Research Department, Hansen's Disease Center, Carville, Louisiana 70721.

A case of lepromatous leprosy with erythema nodosum leprosum (ENL) undergoing treatment with dapsone, rifampin, and thalidomide developed focal tuberculoid granulomas in the ENL lesions. This is the first report known to the authors of a lepromatous leprosy patient in whom ENL and an upgrading reaction occurred simultaneously.

UI	MeSH Term	Description	Entries
D007918	Leprosy	A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.	Hansen's Disease,Hansen Disease
D008297	Male		Males
D004893	Erythema Nodosum	An erythematous eruption commonly associated with drug reactions or infection and characterized by inflammatory nodules that are usually tender, multiple, and bilateral. These nodules are located predominantly on the shins with less common occurrence on the thighs and forearms. They undergo characteristic color changes ending in temporary bruise-like areas. This condition usually subsides in 3-6 weeks without scarring or atrophy.
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D001706	Biopsy	Removal and pathologic examination of specimens from the living body.	Biopsies
D012867	Skin	The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.