-transparent.png){kind=logo}
The effect of oral administration of ammonium acetate for 2, 15, 30, and 100 days on protein synthesis in rat brain was investigated. Although protein synthesis changes were modest, i.e., maximal increase of 24%, there was induction of synthesis and accumulation of a protein with an Mr of 55,000. We show, on the basis of its position on two-dimensional electrophoresis and its immunological reactivity, that this protein is tubulin. Its content increased by 33% as determined by isolation of tubulin after 15 days of oral administration of ammonium and to 49% after 100 days as determined by quantitative immunoblotting.
Related Publications
V Felipo, and
M D Miñana, and
I Azorín, and
S Grisolía
December 2009,
Journal of medical toxicology : official journal of the American College of Medical Toxicology,
V Felipo, and
M D Miñana, and
I Azorín, and
S Grisolía
May 1951,
Recueil de medecine veterinaire,
V Felipo, and
M D Miñana, and
I Azorín, and
S Grisolía
March 1974,
The Journal of biological chemistry,
V Felipo, and
M D Miñana, and
I Azorín, and
S Grisolía
June 1975,
Annals of the New York Academy of Sciences,
V Felipo, and
M D Miñana, and
I Azorín, and
S Grisolía
September 1976,
The Journal of physiology,
V Felipo, and
M D Miñana, and
I Azorín, and
S Grisolía
September 1976,
Biochemical and biophysical research communications,
V Felipo, and
M D Miñana, and
I Azorín, and
S Grisolía
December 1995,
Psychiatry and clinical neurosciences,
V Felipo, and
M D Miñana, and
I Azorín, and
S Grisolía
November 1978,
Nature,
V Felipo, and
M D Miñana, and
I Azorín, and
S Grisolía
March 1979,
Journal of neurochemistry,
V Felipo, and
M D Miñana, and
I Azorín, and
S Grisolía
March 1974,
The Journal of biological chemistry,
