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A 5,000-year-old hunter-gatherer already plagued by Yersinia pestis. 2021
Julian Susat, and
Harald Lübke, and
Alexander Immel, and
Ute Brinker, and
Aija Macāne, and
John Meadows, and
Britta Steer, and
Andreas Tholey, and
Ilga Zagorska, and
Guntis Gerhards, and
Ulrich Schmölcke, and
Mārcis Kalniņš, and
Andre Franke, and
Elīna Pētersone-Gordina, and
Barbara Teßman, and
Mari Tõrv, and
Stefan Schreiber, and
Christian Andree, and
Valdis Bērziņš, and
Almut Nebel, and
Ben Krause-Kyora
Institute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Str. 12, 24105 Kiel, Germany.
A 5,000-year-old Yersinia pestis genome (RV 2039) is reconstructed from a hunter-fisher-gatherer (5300-5050 cal BP) buried at Riņņukalns, Latvia. RV 2039 is the first in a series of ancient strains that evolved shortly after the split of Y. pestis from its antecessor Y. pseudotuberculosis ∼7,000 years ago. The genomic and phylogenetic characteristics of RV 2039 are consistent with the hypothesis that this very early Y. pestis form was most likely less transmissible and maybe even less virulent than later strains. Our data do not support the scenario of a prehistoric pneumonic plague pandemic, as suggested previously for the Neolithic decline. The geographical and temporal distribution of the few prehistoric Y. pestis cases reported so far is more in agreement with single zoonotic events.
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