The effects of intracerebroventricular (ICV) injections of avian pancreatic polypeptide (APP) on food intake, gizzard motility, gastric secretion volume, pH, and pepsin concentration was investigated using 16-20-week-old Single-Comb White Leghorn hens. Birds were stereotaxically cannulated in the right lateral ventricle. In addition, a strain gauge was attached to the gizzard to measure motility and a polyethylene cannula was implanted into the caudoventral margin of the proventriculus to collect glandular secretions. All birds were fasted for 18 hr prior to the injection of APP. In Experiment 1 food was made available immediately following the injection of APP while in Experiment 2 food was withheld for an additional one hr post-injection. The ICV injection of APP significantly increased food intake but had no significant effect on gizzard motility, gastric secretion volume, pH, or pepsin concentration in birds given access to food immediately after injection. In birds which remained fasted after injection, pepsin concentration was decreased by APP injection, but gizzard motility, gastric secretion volume, and pH were not affected. Because ICV injections of APP significantly increased food intake and, in fasted birds, decreased pepsin concentration, it appears that APP is involved in the central nervous system control of food intake and pepsin secretion in the domestic fowl.