Biomaterial Database

Ranson signs and necrosis of the pancreas in acute necrotising pancreatitis. 1988

O Teerenhovi, and I Nordback, and J Isolauri

Department of Surgery, University Central Hospital, Tampere, Finland.

The value of Ranson signs as an indicator of the extent of pancreatic parenchymal necrosis in acute pancreatitis was investigated in 84 patients. Ranson signs could be compared with histologic extent of pancreatic necrosis in 69 cases. The overall mortality rate was 38/84 (45%). The mortality risk increased with the number of positive Ranson signs (correlation coefficient 0.96). The mean total of Ranson signs showed linear increase with extent of parenchymal necrosis up to 75% (from 2.9 signs at no necrosis to 5.4 signs at 75% necrosis, but only 4.7 signs at 76-100%). A similar relationship was found between extent of necrosis and mortality rate. Although the number of positive Ranson signs correlated with the extent of necrosis in resected pancreas (coefficient 0.96), the signs did not adequately predict necrosis in total pancreas. Ranson criteria can be accepted as prognostic signs even when acute necrotizing pancreatitis is treated with resection. The Ranson factors also correlate with necrosis, but do not alone reliably establish its extent in individual cases.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009336	Necrosis	The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
D010179	Pancreas	A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
D010195	Pancreatitis	INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.	Acute Edematous Pancreatitis,Acute Pancreatitis,Pancreatic Parenchyma with Edema,Pancreatic Parenchymal Edema,Pancreatitis, Acute,Pancreatitis, Acute Edematous,Peripancreatic Fat Necrosis,Acute Edematous Pancreatitides,Acute Pancreatitides,Edema, Pancreatic Parenchymal,Edematous Pancreatitides, Acute,Edematous Pancreatitis, Acute,Fat Necrosis, Peripancreatic,Necrosis, Peripancreatic Fat,Pancreatic Parenchymal Edemas,Pancreatitides, Acute,Pancreatitides, Acute Edematous,Parenchymal Edema, Pancreatic,Peripancreatic Fat Necroses
D011379	Prognosis	A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.	Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000208	Acute Disease	Disease having a short and relatively severe course.	Acute Diseases,Disease, Acute,Diseases, Acute
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly