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Leg ulcers in sickle cell disease patients. 2020
Paula Dadalti Granja, and
Samuel Braulio Magalhães Quintão, and
Franciele Perondi, and
Rosemary Bacellar Ferreira de Lima, and
Cláudia Labriola de Medeiros Martins, and
Marcos Arêas Marques, and
Julio Cesar Peclat de Oliveira
Departamento de Medicina Clínica - MMC, Faculdade de Medicina, Universidade Federal Fluminense - UFF, Niterói, RJ, Brasil.
Leg ulcers are the most common cutaneous complication of sickle cell disease. These lesions occur mainly in homozygous forms, are slow to heal and often relapse, causing negative physical, emotional, and economic impacts. In this paper, we discuss the clinical presentation, diagnosis, and pathophysiology of sickle cell leg ulcers and their implications for treatment.
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