Zinc is emerging as a promising biodegradable metal for temporary implant applications. In this work, we investigate the influence of bovine serum albumin (BSA)-the most abundant blood protein in simulated body fluid (SBF) on degradation of pure Zn via electrochemical measurements and long-term immersion. Electrochemical experiments indicate a decrease of the corrosion rate of bare Zn with increasing BSA concentration in solution for short-term exposures. Samples were characterized with scanning electron microscope (SEM) (including energy dispersive spectroscopy [EDS], X-ray photoelectron spectroscopy [XPS], Fourier transform infrared spectroscopy [FTIR], and time-of-flight secondary ion mass spectrometry [TOF-SIMS]) after immersion up to 21 days. Presence of BSA in the electrolyte, decrease the amount of Ca-phosphate precipitation on Zn surface. However, a more compact surface layer formed in the presence of BSA in solution. Most noteworthy, in long-term exposures, BSA enhances localized corrosion of Zn-such detrimental localized attack was not observed in BSA-free solution. We suggest that a sealed space forming between the Zn substrate and a protein adsorption layer restricts mass transport, thus triggering localized corrosion of Zn.