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About 30% of patients with clinical osteoporosis had histological signs of osteomalacia, in spite of normal serum 25-hydroxyvitamin D3 (25-OHD3). The excess osteoid disappeared during treatment with 1alpha-hydroxyvitamin D3 (1alpha-OHD3). These patients might have reduced ability to convert 25-OHD3 to 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3). The intestinal calcium absorption increased during treatment with 1alpha-OHD3, but this was accompanied by a rise in urinary calcium excretion. Photon absorptiometry of the forearm indicated increased bone mineral content during treatment with a daily dose of 2 microgram 1alpha-OHD3 and a supplement of 1 g of calcium. This therapeutic combination, however, caused frequent episodes of hypercalcaemia, so further studies are necessary to evaluate an appropriate dose of 1alpha-OHD3 with or without a calcium supplement.
O H Sørensen, and
R B Andersen, and
M S Christensen, and
T Friis, and
L Hjorth, and
F S Jørgensen, and
B Lund, and
F Melsen, and
L Mosekilde
March 1993,
Bone and mineral,
O H Sørensen, and
R B Andersen, and
M S Christensen, and
T Friis, and
L Hjorth, and
F S Jørgensen, and
B Lund, and
F Melsen, and
L Mosekilde
December 1977,
Clinical endocrinology,
O H Sørensen, and
R B Andersen, and
M S Christensen, and
T Friis, and
L Hjorth, and
F S Jørgensen, and
B Lund, and
F Melsen, and
L Mosekilde
December 1977,
Clinical endocrinology,
O H Sørensen, and
R B Andersen, and
M S Christensen, and
T Friis, and
L Hjorth, and
F S Jørgensen, and
B Lund, and
F Melsen, and
L Mosekilde
December 1977,
Clinical endocrinology,
O H Sørensen, and
R B Andersen, and
M S Christensen, and
T Friis, and
L Hjorth, and
F S Jørgensen, and
B Lund, and
F Melsen, and
L Mosekilde
December 1977,
Clinical endocrinology,
O H Sørensen, and
R B Andersen, and
M S Christensen, and
T Friis, and
L Hjorth, and
F S Jørgensen, and
B Lund, and
F Melsen, and
L Mosekilde
December 1977,
Clinical endocrinology,
O H Sørensen, and
R B Andersen, and
M S Christensen, and
T Friis, and
L Hjorth, and
F S Jørgensen, and
B Lund, and
F Melsen, and
L Mosekilde
December 1977,
Clinical endocrinology,
O H Sørensen, and
R B Andersen, and
M S Christensen, and
T Friis, and
L Hjorth, and
F S Jørgensen, and
B Lund, and
F Melsen, and
L Mosekilde
May 1978,
Proceedings of the National Academy of Sciences of the United States of America,
O H Sørensen, and
R B Andersen, and
M S Christensen, and
T Friis, and
L Hjorth, and
F S Jørgensen, and
B Lund, and
F Melsen, and
L Mosekilde
February 1989,
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
O H Sørensen, and
R B Andersen, and
M S Christensen, and
T Friis, and
L Hjorth, and
F S Jørgensen, and
B Lund, and
F Melsen, and
L Mosekilde
September 1975,
Biochemical and biophysical research communications,
