We have reported a case of Brunner's gland adenoma. Proliferative lesions of these duodenal glands are rare; they are occasionally associated with gastric hyperchlorhydria or chronic pancreatitis. The clinical presentation can vary from vague upper abdominal symptoms with dyspepsia and nausea to diarrhea, jaundice, obstruction, and gastrointestinal bleeding. The diagnosis is usually made by radiologic studies followed by upper endoscopy, which can also provide definitive treatment. As in our case, surgery may be necessary for adequate removal of these lesions.