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Studies are described employing two erythropoietic systems to elucidate regulatory mechanisms that control both normal erythropoiesis and erythroid differentiation of transformed hemopoietic precursors. Evidence is provided suggesting that normal erythroid cell precursors require erythropoietin as a growth factor that regulates the number of precursors capable of differentiating. Murine erythroleukemia cells proliferate without need of erythropoietin; they show a variable, generally low, rate of spontaneous differentiation and a brisk rate of erythropoiesis in response to a variety of chemical agents. Present studies suggest that these chemical inducers initiate a series of events including cell surface related changes, alterations in cell cycle kinetics, and modifications of chromatin and DNA structure which result in the irreversible commitment of these leukemia cells to erythroid differentiation and the synthesis of red-cell-specific products.
R A Rifkind, and
P A Marks, and
A Bank, and
M Terada, and
R C Reuben, and
G M Maniatis, and
E Fibach, and
U Nudel, and
J E Salmon, and
Y Gazitt
May 2003,
Oncogene,
R A Rifkind, and
P A Marks, and
A Bank, and
M Terada, and
R C Reuben, and
G M Maniatis, and
E Fibach, and
U Nudel, and
J E Salmon, and
Y Gazitt
January 1979,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
R A Rifkind, and
P A Marks, and
A Bank, and
M Terada, and
R C Reuben, and
G M Maniatis, and
E Fibach, and
U Nudel, and
J E Salmon, and
Y Gazitt
January 1981,
Current topics in microbiology and immunology,
R A Rifkind, and
P A Marks, and
A Bank, and
M Terada, and
R C Reuben, and
G M Maniatis, and
E Fibach, and
U Nudel, and
J E Salmon, and
Y Gazitt
February 2005,
Blood,
R A Rifkind, and
P A Marks, and
A Bank, and
M Terada, and
R C Reuben, and
G M Maniatis, and
E Fibach, and
U Nudel, and
J E Salmon, and
Y Gazitt
August 1971,
Nature,
R A Rifkind, and
P A Marks, and
A Bank, and
M Terada, and
R C Reuben, and
G M Maniatis, and
E Fibach, and
U Nudel, and
J E Salmon, and
Y Gazitt
January 1978,
Blood cells,
R A Rifkind, and
P A Marks, and
A Bank, and
M Terada, and
R C Reuben, and
G M Maniatis, and
E Fibach, and
U Nudel, and
J E Salmon, and
Y Gazitt
January 1989,
Developmental and comparative immunology,
R A Rifkind, and
P A Marks, and
A Bank, and
M Terada, and
R C Reuben, and
G M Maniatis, and
E Fibach, and
U Nudel, and
J E Salmon, and
Y Gazitt
April 1989,
Carcinogenesis,
R A Rifkind, and
P A Marks, and
A Bank, and
M Terada, and
R C Reuben, and
G M Maniatis, and
E Fibach, and
U Nudel, and
J E Salmon, and
Y Gazitt
February 1994,
Cellular signalling,
R A Rifkind, and
P A Marks, and
A Bank, and
M Terada, and
R C Reuben, and
G M Maniatis, and
E Fibach, and
U Nudel, and
J E Salmon, and
Y Gazitt
January 1994,
Molekuliarnaia biologiia,
