-transparent.png){kind=logo}
Antibody landscape against SARS-CoV-2 reveals significant differences between non-structural/accessory and structural proteins. 2021
Yang Li, and
Zhaowei Xu, and
Qing Lei, and
Dan-Yun Lai, and
Hongyan Hou, and
He-Wei Jiang, and
Yun-Xiao Zheng, and
Xue-Ning Wang, and
Jiaoxiang Wu, and
Ming-Liang Ma, and
Bo Zhang, and
Hong Chen, and
Caizheng Yu, and
Jun-Biao Xue, and
Hai-Nan Zhang, and
Huan Qi, and
Shu-Juan Guo, and
Yandi Zhang, and
Xiaosong Lin, and
Zongjie Yao, and
Huiming Sheng, and
Ziyong Sun, and
Feng Wang, and
Xionglin Fan, and
Sheng-Ce Tao
Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
The immunogenicity of the SARS-CoV-2 proteome is largely unknown, especially for non-structural proteins and accessory proteins. In this study, we collect 2,360 COVID-19 sera and 601 control sera. We analyze these sera on a protein microarray with 20 proteins of SARS-CoV-2, building an antibody response landscape for immunoglobulin (Ig)G and IgM. Non-structural proteins and accessory proteins NSP1, NSP7, NSP8, RdRp, ORF3b, and ORF9b elicit prevalent IgG responses. The IgG patterns and dynamics of non-structural/accessory proteins are different from those of the S and N proteins. The IgG responses against these six proteins are associated with disease severity and clinical outcome, and they decline sharply about 20Â days after symptom onset. In non-survivors, a sharp decrease of IgG antibodies against S1 and N proteins before death is observed. The global antibody responses to non-structural/accessory proteins revealed here may facilitate a deeper understanding of SARS-CoV-2 immunology.
Related Publications
Yang Li, and
Zhaowei Xu, and
Qing Lei, and
Dan-Yun Lai, and
Hongyan Hou, and
He-Wei Jiang, and
Yun-Xiao Zheng, and
Xue-Ning Wang, and
Jiaoxiang Wu, and
Ming-Liang Ma, and
Bo Zhang, and
Hong Chen, and
Caizheng Yu, and
Jun-Biao Xue, and
Hai-Nan Zhang, and
Huan Qi, and
Shu-Juan Guo, and
Yandi Zhang, and
Xiaosong Lin, and
Zongjie Yao, and
Huiming Sheng, and
Ziyong Sun, and
Feng Wang, and
Xionglin Fan, and
Sheng-Ce Tao
January 2021,
medRxiv : the preprint server for health sciences,
Yang Li, and
Zhaowei Xu, and
Qing Lei, and
Dan-Yun Lai, and
Hongyan Hou, and
He-Wei Jiang, and
Yun-Xiao Zheng, and
Xue-Ning Wang, and
Jiaoxiang Wu, and
Ming-Liang Ma, and
Bo Zhang, and
Hong Chen, and
Caizheng Yu, and
Jun-Biao Xue, and
Hai-Nan Zhang, and
Huan Qi, and
Shu-Juan Guo, and
Yandi Zhang, and
Xiaosong Lin, and
Zongjie Yao, and
Huiming Sheng, and
Ziyong Sun, and
Feng Wang, and
Xionglin Fan, and
Sheng-Ce Tao
August 2023,
International journal of molecular sciences,
Yang Li, and
Zhaowei Xu, and
Qing Lei, and
Dan-Yun Lai, and
Hongyan Hou, and
He-Wei Jiang, and
Yun-Xiao Zheng, and
Xue-Ning Wang, and
Jiaoxiang Wu, and
Ming-Liang Ma, and
Bo Zhang, and
Hong Chen, and
Caizheng Yu, and
Jun-Biao Xue, and
Hai-Nan Zhang, and
Huan Qi, and
Shu-Juan Guo, and
Yandi Zhang, and
Xiaosong Lin, and
Zongjie Yao, and
Huiming Sheng, and
Ziyong Sun, and
Feng Wang, and
Xionglin Fan, and
Sheng-Ce Tao
January 2023,
Immunobiology,
Yang Li, and
Zhaowei Xu, and
Qing Lei, and
Dan-Yun Lai, and
Hongyan Hou, and
He-Wei Jiang, and
Yun-Xiao Zheng, and
Xue-Ning Wang, and
Jiaoxiang Wu, and
Ming-Liang Ma, and
Bo Zhang, and
Hong Chen, and
Caizheng Yu, and
Jun-Biao Xue, and
Hai-Nan Zhang, and
Huan Qi, and
Shu-Juan Guo, and
Yandi Zhang, and
Xiaosong Lin, and
Zongjie Yao, and
Huiming Sheng, and
Ziyong Sun, and
Feng Wang, and
Xionglin Fan, and
Sheng-Ce Tao
January 2022,
Journal of biomolecular structure & dynamics,
Yang Li, and
Zhaowei Xu, and
Qing Lei, and
Dan-Yun Lai, and
Hongyan Hou, and
He-Wei Jiang, and
Yun-Xiao Zheng, and
Xue-Ning Wang, and
Jiaoxiang Wu, and
Ming-Liang Ma, and
Bo Zhang, and
Hong Chen, and
Caizheng Yu, and
Jun-Biao Xue, and
Hai-Nan Zhang, and
Huan Qi, and
Shu-Juan Guo, and
Yandi Zhang, and
Xiaosong Lin, and
Zongjie Yao, and
Huiming Sheng, and
Ziyong Sun, and
Feng Wang, and
Xionglin Fan, and
Sheng-Ce Tao
November 2020,
Trends in immunology,
Yang Li, and
Zhaowei Xu, and
Qing Lei, and
Dan-Yun Lai, and
Hongyan Hou, and
He-Wei Jiang, and
Yun-Xiao Zheng, and
Xue-Ning Wang, and
Jiaoxiang Wu, and
Ming-Liang Ma, and
Bo Zhang, and
Hong Chen, and
Caizheng Yu, and
Jun-Biao Xue, and
Hai-Nan Zhang, and
Huan Qi, and
Shu-Juan Guo, and
Yandi Zhang, and
Xiaosong Lin, and
Zongjie Yao, and
Huiming Sheng, and
Ziyong Sun, and
Feng Wang, and
Xionglin Fan, and
Sheng-Ce Tao
January 2022,
Journal of biomolecular structure & dynamics,
Yang Li, and
Zhaowei Xu, and
Qing Lei, and
Dan-Yun Lai, and
Hongyan Hou, and
He-Wei Jiang, and
Yun-Xiao Zheng, and
Xue-Ning Wang, and
Jiaoxiang Wu, and
Ming-Liang Ma, and
Bo Zhang, and
Hong Chen, and
Caizheng Yu, and
Jun-Biao Xue, and
Hai-Nan Zhang, and
Huan Qi, and
Shu-Juan Guo, and
Yandi Zhang, and
Xiaosong Lin, and
Zongjie Yao, and
Huiming Sheng, and
Ziyong Sun, and
Feng Wang, and
Xionglin Fan, and
Sheng-Ce Tao
January 2021,
Current protein & peptide science,
Yang Li, and
Zhaowei Xu, and
Qing Lei, and
Dan-Yun Lai, and
Hongyan Hou, and
He-Wei Jiang, and
Yun-Xiao Zheng, and
Xue-Ning Wang, and
Jiaoxiang Wu, and
Ming-Liang Ma, and
Bo Zhang, and
Hong Chen, and
Caizheng Yu, and
Jun-Biao Xue, and
Hai-Nan Zhang, and
Huan Qi, and
Shu-Juan Guo, and
Yandi Zhang, and
Xiaosong Lin, and
Zongjie Yao, and
Huiming Sheng, and
Ziyong Sun, and
Feng Wang, and
Xionglin Fan, and
Sheng-Ce Tao
January 2021,
Frontiers in immunology,
Yang Li, and
Zhaowei Xu, and
Qing Lei, and
Dan-Yun Lai, and
Hongyan Hou, and
He-Wei Jiang, and
Yun-Xiao Zheng, and
Xue-Ning Wang, and
Jiaoxiang Wu, and
Ming-Liang Ma, and
Bo Zhang, and
Hong Chen, and
Caizheng Yu, and
Jun-Biao Xue, and
Hai-Nan Zhang, and
Huan Qi, and
Shu-Juan Guo, and
Yandi Zhang, and
Xiaosong Lin, and
Zongjie Yao, and
Huiming Sheng, and
Ziyong Sun, and
Feng Wang, and
Xionglin Fan, and
Sheng-Ce Tao
June 2024,
Microbiology and immunology,
Yang Li, and
Zhaowei Xu, and
Qing Lei, and
Dan-Yun Lai, and
Hongyan Hou, and
He-Wei Jiang, and
Yun-Xiao Zheng, and
Xue-Ning Wang, and
Jiaoxiang Wu, and
Ming-Liang Ma, and
Bo Zhang, and
Hong Chen, and
Caizheng Yu, and
Jun-Biao Xue, and
Hai-Nan Zhang, and
Huan Qi, and
Shu-Juan Guo, and
Yandi Zhang, and
Xiaosong Lin, and
Zongjie Yao, and
Huiming Sheng, and
Ziyong Sun, and
Feng Wang, and
Xionglin Fan, and
Sheng-Ce Tao
January 2020,
BioMed research international,
