AGPAT3 Gene polymorphisms are associated with milk production traits in Chinese Holstein cows. 2021

Xiaomei Sun, and Yan Liang, and Qisong Gao, and Jiahe Guo, and Cheng Tang, and Kerong Shi, and Zhangping Yang, and Yongjiang Mao
Key Laboratory of Animal Genetics & Breeding and Molecular Design of Jiangsu Province, Yangzhou University, Yangzhou225009, China.

The current study reports the identification of previously undiscovered single-nucleotide polymorphisms (SNPs) in the bovine AGPAT3 gene and further investigates their associations with milk production traits. Our results demonstrate that the major allele C of the SNP g.12264 C > T is positively correlated with test-day milk yield, protein percentage and 305-day milk yield. Importantly, in silico analysis showed that the C/T transition at this locus gives rise to two new transcription factor binding sites (TFBS), E2F1 and Nkx3-2. Polymorphism g.18658 G > A was the only SNP associated with milk urea nitrogen (MUN) with the G allele related to an increase in milk urea nitrogen as well as fat percentage. The GG genotype of SNP g.28731 A > G was associated with the highest fat and protein percentage and lowest 305-day milk yield and somatic cell score (SCS). The association between AGPAT3 locus and milk production traits could be utilized in marker-assisted selection for the genetic improvement of milk production traits and, probably in conjunction with other traits, for selection to improve fitness of dairy cattle.

UI MeSH Term Description Entries
D007774 Lactation The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN. Lactation, Prolonged,Milk Secretion,Lactations, Prolonged,Milk Secretions,Prolonged Lactation,Prolonged Lactations
D008892 Milk The off-white liquid secreted by the mammary glands of humans and other mammals. It contains proteins, sugar, lipids, vitamins, and minerals. Cow Milk,Cow's Milk,Milk, Cow,Milk, Cow's
D002417 Cattle Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor. Beef Cow,Bos grunniens,Bos indicus,Bos indicus Cattle,Bos taurus,Cow,Cow, Domestic,Dairy Cow,Holstein Cow,Indicine Cattle,Taurine Cattle,Taurus Cattle,Yak,Zebu,Beef Cows,Bos indicus Cattles,Cattle, Bos indicus,Cattle, Indicine,Cattle, Taurine,Cattle, Taurus,Cattles, Bos indicus,Cattles, Indicine,Cattles, Taurine,Cattles, Taurus,Cow, Beef,Cow, Dairy,Cow, Holstein,Cows,Dairy Cows,Domestic Cow,Domestic Cows,Indicine Cattles,Taurine Cattles,Taurus Cattles,Yaks,Zebus
D002681 China A country spanning from central Asia to the Pacific Ocean. Inner Mongolia,Manchuria,People's Republic of China,Sinkiang,Mainland China
D005260 Female Females
D005787 Gene Frequency The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION. Allele Frequency,Genetic Equilibrium,Equilibrium, Genetic,Allele Frequencies,Frequencies, Allele,Frequencies, Gene,Frequency, Allele,Frequency, Gene,Gene Frequencies
D005838 Genotype The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS. Genogroup,Genogroups,Genotypes
D000217 Acyltransferases Enzymes from the transferase class that catalyze the transfer of acyl groups from donor to acceptor, forming either esters or amides. (From Enzyme Nomenclature 1992) EC 2.3. Acyltransferase
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D020641 Polymorphism, Single Nucleotide A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population. SNPs,Single Nucleotide Polymorphism,Nucleotide Polymorphism, Single,Nucleotide Polymorphisms, Single,Polymorphisms, Single Nucleotide,Single Nucleotide Polymorphisms

Related Publications

Xiaomei Sun, and Yan Liang, and Qisong Gao, and Jiahe Guo, and Cheng Tang, and Kerong Shi, and Zhangping Yang, and Yongjiang Mao
November 2018, The Journal of dairy research,
Xiaomei Sun, and Yan Liang, and Qisong Gao, and Jiahe Guo, and Cheng Tang, and Kerong Shi, and Zhangping Yang, and Yongjiang Mao
January 2022, Frontiers in genetics,
Xiaomei Sun, and Yan Liang, and Qisong Gao, and Jiahe Guo, and Cheng Tang, and Kerong Shi, and Zhangping Yang, and Yongjiang Mao
March 2012, Molecular biology reports,
Xiaomei Sun, and Yan Liang, and Qisong Gao, and Jiahe Guo, and Cheng Tang, and Kerong Shi, and Zhangping Yang, and Yongjiang Mao
December 2020, Animals : an open access journal from MDPI,
Xiaomei Sun, and Yan Liang, and Qisong Gao, and Jiahe Guo, and Cheng Tang, and Kerong Shi, and Zhangping Yang, and Yongjiang Mao
January 2015, PloS one,
Xiaomei Sun, and Yan Liang, and Qisong Gao, and Jiahe Guo, and Cheng Tang, and Kerong Shi, and Zhangping Yang, and Yongjiang Mao
September 2022, Bioengineering (Basel, Switzerland),
Xiaomei Sun, and Yan Liang, and Qisong Gao, and Jiahe Guo, and Cheng Tang, and Kerong Shi, and Zhangping Yang, and Yongjiang Mao
November 2014, BMC genetics,
Xiaomei Sun, and Yan Liang, and Qisong Gao, and Jiahe Guo, and Cheng Tang, and Kerong Shi, and Zhangping Yang, and Yongjiang Mao
October 2016, Molecular and cellular probes,
Xiaomei Sun, and Yan Liang, and Qisong Gao, and Jiahe Guo, and Cheng Tang, and Kerong Shi, and Zhangping Yang, and Yongjiang Mao
April 2024, Animals : an open access journal from MDPI,
Xiaomei Sun, and Yan Liang, and Qisong Gao, and Jiahe Guo, and Cheng Tang, and Kerong Shi, and Zhangping Yang, and Yongjiang Mao
January 2011, Animal biotechnology,
Copied contents to your clipboard!