IgM and IgG antibody responses after immunization of children with inactivated monovalent (A/New Jersey/76) and bivalent (A/New Jersey/76-A/Victoria/75) influenza virus vaccines. 1977

K M Boyer, and J D Cherry, and R C Welliver, and J P Dudley, and J Deseda-Tous, and J M Zahradnik, and P J Krause, and M J Spencer, and Y J Bryson, and A J Garakian

The character of the immune response to inactivated monovalent influenza A/New Jersey/76 and bivalent influenza A/New Jersey/76-A/Victoria/75 vaccines was studied in children six months to 18 years of age. Titers of hemagglutination-inhibiting antibody in sera taken after vaccination were measured before and after treatment with 2-mercaptoethanol. IgG antibody predominated in responses to the influenza A/Victoria/75 component of bivalent vaccines. In contrast, specific IgM antibody to influenza A/New Jersey/76 virus developed after administration of both monovalent and bivalent vaccines and appeared to characterize the immune response to this antigenic "shift" strain in children. Prevalences of IgM antibody against influenza A/New Jersey/76 virus did not differ significantly by age. This finding implies that type rather than extent of previous experience with influenza determines the IgM antibody response to an antigenic "shifts." Split-product vaccines produced significantly fewer IgM antibody responses to influenza A/New Jersey/76 virus than did whole-virus vaccines, a phenomenon that may correlate with their diminished reactogenicity and immunogenicity in children.

UI MeSH Term Description Entries
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007075 Immunoglobulin M A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally was called a macroglobulin. Gamma Globulin, 19S,IgM,IgM Antibody,IgM1,IgM2,19S Gamma Globulin,Antibody, IgM
D007223 Infant A child between 1 and 23 months of age. Infants
D007252 Influenza Vaccines Vaccines used to prevent infection by viruses in the family ORTHOMYXOVIRIDAE. It includes both killed and attenuated vaccines. The composition of the vaccines is changed each year in response to antigenic shifts and changes in prevalence of influenza virus strains. The flu vaccines may be mono- or multi-valent, which contains one or more ALPHAINFLUENZAVIRUS and BETAINFLUENZAVIRUS strains. Flu Vaccine,Influenzavirus Vaccine,Monovalent Influenza Vaccine,Universal Flu Vaccine,Universal Influenza Vaccine,Flu Vaccines,High-Dose Trivalent Influenza Vaccine,Influenza Vaccine,Influenza Virus Vaccine,Influenza Virus Vaccines,Influenzavirus Vaccines,Intranasal Live-Attenuated Influenza Vaccine,LAIV Vaccine,Monovalent Influenza Vaccines,Quadrivalent Influenza Vaccine,Trivalent Influenza Vaccine,Trivalent Live Attenuated Influenza Vaccine,Universal Flu Vaccines,Universal Influenza Vaccines,Flu Vaccine, Universal,High Dose Trivalent Influenza Vaccine,Influenza Vaccine, Monovalent,Influenza Vaccine, Quadrivalent,Influenza Vaccine, Trivalent,Influenza Vaccine, Universal,Intranasal Live Attenuated Influenza Vaccine,Vaccine, Flu,Vaccine, Influenza,Vaccine, Influenza Virus,Vaccine, Influenzavirus,Vaccine, LAIV,Vaccine, Monovalent Influenza,Vaccine, Quadrivalent Influenza,Vaccine, Trivalent Influenza,Virus Vaccine, Influenza
D008623 Mercaptoethanol A water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation. 2-ME,2-Mercaptoethanol,2 Mercaptoethanol
D009515 New Jersey State bounded on the north by New York and Pennsylvania, on the east by New York and the Atlantic Ocean, on the south by Delaware Bay, and on the west by Pennsylvania.
D009980 Influenza A virus The type species of the genus ALPHAINFLUENZAVIRUS that causes influenza and other diseases in humans and animals. Antigenic variation occurs frequently between strains, allowing classification into subtypes and variants. Transmission is usually by aerosol (human and most non-aquatic hosts) or waterborne (ducks). Infected birds shed the virus in their saliva, nasal secretions, and feces. Alphainfluenzavirus influenzae,Avian Orthomyxovirus Type A,FLUAV,Fowl Plague Virus,Human Influenza A Virus,Influenza Virus Type A,Influenza Viruses Type A,Myxovirus influenzae-A hominis,Myxovirus influenzae-A suis,Myxovirus pestis galli,Orthomyxovirus Type A,Orthomyxovirus Type A, Avian,Orthomyxovirus Type A, Human,Orthomyxovirus Type A, Porcine,Pestis galli Myxovirus,Fowl Plague Viruses,Influenza A viruses,Myxovirus influenzae A hominis,Myxovirus influenzae A suis,Myxovirus, Pestis galli,Myxoviruses, Pestis galli,Pestis galli Myxoviruses,Plague Virus, Fowl,Virus, Fowl Plague
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D002986 Clinical Trials as Topic Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries. Clinical Trial as Topic

Related Publications

K M Boyer, and J D Cherry, and R C Welliver, and J P Dudley, and J Deseda-Tous, and J M Zahradnik, and P J Krause, and M J Spencer, and Y J Bryson, and A J Garakian
December 1977, The Journal of infectious diseases,
K M Boyer, and J D Cherry, and R C Welliver, and J P Dudley, and J Deseda-Tous, and J M Zahradnik, and P J Krause, and M J Spencer, and Y J Bryson, and A J Garakian
December 1977, The Journal of infectious diseases,
K M Boyer, and J D Cherry, and R C Welliver, and J P Dudley, and J Deseda-Tous, and J M Zahradnik, and P J Krause, and M J Spencer, and Y J Bryson, and A J Garakian
December 1977, The Journal of infectious diseases,
K M Boyer, and J D Cherry, and R C Welliver, and J P Dudley, and J Deseda-Tous, and J M Zahradnik, and P J Krause, and M J Spencer, and Y J Bryson, and A J Garakian
December 1977, The Journal of infectious diseases,
K M Boyer, and J D Cherry, and R C Welliver, and J P Dudley, and J Deseda-Tous, and J M Zahradnik, and P J Krause, and M J Spencer, and Y J Bryson, and A J Garakian
December 1977, The Journal of infectious diseases,
K M Boyer, and J D Cherry, and R C Welliver, and J P Dudley, and J Deseda-Tous, and J M Zahradnik, and P J Krause, and M J Spencer, and Y J Bryson, and A J Garakian
December 1977, The Journal of infectious diseases,
K M Boyer, and J D Cherry, and R C Welliver, and J P Dudley, and J Deseda-Tous, and J M Zahradnik, and P J Krause, and M J Spencer, and Y J Bryson, and A J Garakian
December 1977, The Journal of infectious diseases,
K M Boyer, and J D Cherry, and R C Welliver, and J P Dudley, and J Deseda-Tous, and J M Zahradnik, and P J Krause, and M J Spencer, and Y J Bryson, and A J Garakian
December 1977, The Journal of infectious diseases,
K M Boyer, and J D Cherry, and R C Welliver, and J P Dudley, and J Deseda-Tous, and J M Zahradnik, and P J Krause, and M J Spencer, and Y J Bryson, and A J Garakian
February 1980, The Journal of pediatrics,
K M Boyer, and J D Cherry, and R C Welliver, and J P Dudley, and J Deseda-Tous, and J M Zahradnik, and P J Krause, and M J Spencer, and Y J Bryson, and A J Garakian
December 1978, The Australian journal of experimental biology and medical science,
Copied contents to your clipboard!