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Retinoic acid (RA), the acid form of vitamin A, is shown to enhance the synthesis of nerve growth factor (NGF) in cultures of mouse L cells. Maximal stimulation was observed in cells growing in a serum-free medium supplemented with 10(-6)M RA during 48 h. The drug increased both the level of NGF mRNA and the amount of mature NGF protein secreted by the cells. RA was previously reported to increase the number of NGF receptors on some neuroblastoma cells (Haskell et al., 1987 Cell and Tiss. Res., 247, 67-73). It seems, therefore, that RA may influence nerve cell differentiation by promoting both the synthesis of the neurotrophic factor and the responsiveness of target cells.
D Wion, and
R Houlgatte, and
N Barbot, and
P Barrand, and
E Dicou, and
P Brachet
May 1991,
Molecular and cellular biology,
D Wion, and
R Houlgatte, and
N Barbot, and
P Barrand, and
E Dicou, and
P Brachet
November 1992,
Differentiation; research in biological diversity,
D Wion, and
R Houlgatte, and
N Barbot, and
P Barrand, and
E Dicou, and
P Brachet
November 1991,
Plasmid,
D Wion, and
R Houlgatte, and
N Barbot, and
P Barrand, and
E Dicou, and
P Brachet
May 1992,
Journal of cellular physiology,
D Wion, and
R Houlgatte, and
N Barbot, and
P Barrand, and
E Dicou, and
P Brachet
April 1992,
Archives of biochemistry and biophysics,
D Wion, and
R Houlgatte, and
N Barbot, and
P Barrand, and
E Dicou, and
P Brachet
January 1985,
Gene,
D Wion, and
R Houlgatte, and
N Barbot, and
P Barrand, and
E Dicou, and
P Brachet
June 1994,
Molecular endocrinology (Baltimore, Md.),
D Wion, and
R Houlgatte, and
N Barbot, and
P Barrand, and
E Dicou, and
P Brachet
January 1995,
Archives of dermatological research,
D Wion, and
R Houlgatte, and
N Barbot, and
P Barrand, and
E Dicou, and
P Brachet
September 1995,
Brain research. Molecular brain research,
D Wion, and
R Houlgatte, and
N Barbot, and
P Barrand, and
E Dicou, and
P Brachet
June 1995,
Molecular and cellular endocrinology,
