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Genetic mapping and phenotypic analysis of shot in Drosophila melanogaster. 2021
Elyse M Talley, and
Charlie T Watts, and
Sonia Aboyer, and
Madeline G Adamson, and
Harriet Ab Akoto, and
Haley Altemus, and
Philip J Avella, and
Rebecca Bailey, and
Elizabeth R Bell, and
Katheryn L Bell, and
Kelsey Breneman, and
Jessica S Burkhart, and
Logan J Chanley, and
Savannah S Cook, and
Mackenzie T DesLaurier, and
Timothy R Dorsey, and
Cassandra J Doyle, and
Merris E Egloff, and
Ayoola S Fasawe, and
Katy K Garcia, and
Nathaniel P Graves, and
Tyler K Gray, and
Evan M Gustafson, and
Makayla J Hall, and
Jaden D Hayes, and
Lindsay J Holic, and
Brice A Jarvis, and
Piotr S Klos, and
Sidney Kritzmire, and
Lera Kuzovko, and
Edwyna Lainez, and
Shamerra McCoy, and
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Kelley Osborn, and
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Kylee Peck, and
Robyn Pitt, and
Matthew E Platta, and
Brianna Powell, and
Katalina Rodriguez, and
Clara Ruiz, and
Mariah N Schaefer, and
Amanda B Shields, and
Jasmine B Smiley, and
Briona Stauffer, and
Devan Straub, and
John L Sweeney, and
Kaitlyn M Termine, and
Brett Thomas, and
Sophia D Toth, and
Taylor R Veile, and
Kayla S Walker, and
Paige N Webster, and
Brian J Woodard, and
Quentin L Yoder, and
McKenzie K Young, and
McKenzie L Zeedyk, and
Logan N Ziegler, and
Kayla L Bieser, and
David P Puthoff, and
Joyce Stamm, and
Alysia D Vrailas-Mortimer, and
Jacob D Kagey, and
Julie A Merkle
University of Evansville, Evansville, IN USA.
Genetic screens are used to identify genes involved in specific biological processes. An EMS mutagenesis screen in Drosophila melanogaster identified growth control phenotypes in the developing eye. One mutant line from this screen, H.3.2, was phenotypically characterized using the FLP/FRT system and genetically mapped by complementation analysis and genomic sequencing by undergraduate students participating in the multi-institution Fly-CURE consortium. H.3.2 was found to have a nonsense mutation in short stop (shot), anortholog of the mammalian spectraplakin dystonin (DST). shot and DST are involved in cytoskeletal organization and play roles during cell growth and proliferation.
| UI | MeSH Term | Description | Entries |
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