BIOMAT Database Logo BIOMAT Database Logo

Effect of microsomal leucine aminopeptidase from human placenta (microsomal P-LAP) on pressor response to infused angiotensin II (A-II) in rat. 1987

S Mizutani, and H Taira, and O Kurauchi, and Y Ito, and H Imaizumi, and M Furuhashi, and O Narita, and Y Tomoda
Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Japan.

The role of microsomal placental leucine aminopeptidase (microsomal P-LAP) in the decreased pressor responsiveness to angiotensin II (A-II) in pregnancy was studied. Appreciable amounts of microsomal P-LAP activity were found in rat placenta. The similar dose to the endogenous activity, of human microsomal P-LAP exogenously administered to rats, resulted in significant decrease in the response to A-II. Bestatin, an inhibitor of the microsomal leucine aminopeptidase administered to pregnant rats, enhanced the A-II response. Therefore our present study suggests such refractoriness in response to A-II in pregnancy is due to increased inactivation by the microsomal P-LAP. It was also suggested that prostaglandins were not involved in such refractoriness by the experiments with indomethacin.

UI MeSH Term Description Entries
D007213 Indomethacin A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES. Amuno,Indocid,Indocin,Indomet 140,Indometacin,Indomethacin Hydrochloride,Metindol,Osmosin
D007930 Leucine An essential branched-chain amino acid important for hemoglobin formation. L-Leucine,Leucine, L-Isomer,L-Isomer Leucine,Leucine, L Isomer
D007931 Leucyl Aminopeptidase A zinc containing enzyme of the hydrolase class that catalyzes the removal of the N-terminal amino acid from most L-peptides, particularly those with N-terminal leucine residues but not those with N-terminal lysine or arginine residues. This occurs in tissue cell cytosol, with high activity in the duodenum, liver, and kidney. The activity of this enzyme is commonly assayed using a leucine arylamide chromogenic substrate such as leucyl beta-naphthylamide. Cytosol Aminopeptidase,Leucine Aminopeptidase,L-Leucylnaphthylamidase,Methoxyleucine Aminopeptidase,Peptidase S,Zinc-Manganese-Leucine Aminopeptidase,Aminopeptidase, Cytosol,Aminopeptidase, Leucine,Aminopeptidase, Leucyl,Aminopeptidase, Methoxyleucine,Aminopeptidase, Zinc-Manganese-Leucine,Zinc Manganese Leucine Aminopeptidase
D008297 Male Males
D008861 Microsomes Artifactual vesicles formed from the endoplasmic reticulum when cells are disrupted. They are isolated by differential centrifugation and are composed of three structural features: rough vesicles, smooth vesicles, and ribosomes. Numerous enzyme activities are associated with the microsomal fraction. (Glick, Glossary of Biochemistry and Molecular Biology, 1990; from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed) Microsome
D010920 Placenta A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES). Placentoma, Normal,Placentome,Placentas,Placentomes
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D005260 Female Females

Related Publications

S Mizutani, and H Taira, and O Kurauchi, and Y Ito, and H Imaizumi, and M Furuhashi, and O Narita, and Y Tomoda
Inactivation of oxytocin and angiotensin II by placental leucine aminopeptidase (P-LAP).
April 1982, Nihon Sanka Fujinka Gakkai zasshi,
S Mizutani, and H Taira, and O Kurauchi, and Y Ito, and H Imaizumi, and M Furuhashi, and O Narita, and Y Tomoda
Human placental leucine aminopeptidase (P-LAP) as a hypotensive agent.
July 1982, Experientia,
S Mizutani, and H Taira, and O Kurauchi, and Y Ito, and H Imaizumi, and M Furuhashi, and O Narita, and Y Tomoda
Thromboxane mediation of the pressor response to infused angiotensin II.
March 1990, American journal of hypertension,
S Mizutani, and H Taira, and O Kurauchi, and Y Ito, and H Imaizumi, and M Furuhashi, and O Narita, and Y Tomoda
[Estimation of placental leucine aminopeptidase (P-LAP) in pregnancy sera].
December 1984, Nihon Sanka Fujinka Gakkai zasshi,
S Mizutani, and H Taira, and O Kurauchi, and Y Ito, and H Imaizumi, and M Furuhashi, and O Narita, and Y Tomoda
Plasma angiotensin I concentration and serum placental leucine aminopeptidase (P-LAP) activities in puerperal hypertension.
September 1993, Research communications in chemical pathology and pharmacology,
S Mizutani, and H Taira, and O Kurauchi, and Y Ito, and H Imaizumi, and M Furuhashi, and O Narita, and Y Tomoda
The effect of 1-sarcosine, 8-leucyl angiotensin II on the pressor effect of infused angiotensin II.
May 1974, Archives internationales de pharmacodynamie et de therapie,
S Mizutani, and H Taira, and O Kurauchi, and Y Ito, and H Imaizumi, and M Furuhashi, and O Narita, and Y Tomoda
The origin of human seminal leucine aminopeptidase (LAP).
June 1979, Fertility and sterility,
S Mizutani, and H Taira, and O Kurauchi, and Y Ito, and H Imaizumi, and M Furuhashi, and O Narita, and Y Tomoda
Effects of progesterone and estradiol on aminopeptidase A (AAP) and leucine aminopeptidase (LAP) activities in the pregnancy serum and placenta of the rat.
April 1989, Experimental and clinical endocrinology,
S Mizutani, and H Taira, and O Kurauchi, and Y Ito, and H Imaizumi, and M Furuhashi, and O Narita, and Y Tomoda
Alteration of circulating Placental Leucine Aminopeptidase (P-LAP) activity in preeclampsia.
January 2010, Neuro endocrinology letters,
S Mizutani, and H Taira, and O Kurauchi, and Y Ito, and H Imaizumi, and M Furuhashi, and O Narita, and Y Tomoda
Placental leucine aminopeptidase (P-LAP) expression is associated with chemosensitivity in human endometrial carcinoma.
November 2004, Gynecologic oncology,
Copied contents to your clipboard!