Biomaterial Database

[Diabetic cardiomyopathy in mild diabetics: evaluation by thallium-201 scintigraphy and exercise radionuclide ventriculography]. 1986

K Amano, and T Sakamoto, and J Oku, and K Fujinami, and T Sugimoto

Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo.

Forty mildly diabetic men, with a mean age of 49 +/- 9.7 years, and without clinical or exercise electrocardiographic evidence of ischemic cardiac disease, participated in a study consisting of exercise thallium-201 myocardial scintigraphy and exercise radionuclide ventriculography. 1. Among the 40 patients, 16 (40%) showed no filling defect (negative cases). Mild defects (mild cases) and moderate defects (moderate cases) were observed in 12 and 12 cases, respectively. 2. The percent washout ratio was decreased in none of the 16 negative cases, in three of the 12 mild cases, and in 11 of the 12 moderate cases. 3. There were no significant statistical differences in age, duration of diabetes, fasting blood sugar, HbA1c, serum cholesterol, smoking or blood pressure. Percent of ideal body weight was greater in moderate cases (121 +/- 15%) compared to negative or mild cases (103 +/- 9%, 108 +/- 9%) (p less than 0.01). 4. The percent fractional shortening was decreased in mild cases and in moderate cases (34.6 +/- 6.3%, 32.6 +/- 8.4%) compared to negative cases (41.7 +/- 4.9%) (p less than 0.01). Weissler's index (PEP/ET) was higher in moderate cases (0.42 +/- 0.09) compared to negative or mild cases (0.35 +/- 0.05, 0.36 +/- 0.06) (p less than 0.05). 5. Left ventricular wall motion was abnormal on echocardiography in none of the 16 negative cases, in three of the 12 mild cases and in seven of the moderate cases. The site of echocardiographically abnormal wall motion coincided with the defect area on myocardial scintigraphy in six cases, but not in four cases. 6. Radionuclide ventriculographic studies statistically showed no significant differences in ejection fraction (EF), 1/3EF, time to peak ejection (TPE), ejection time (ET), peak ejection rate (PER), 1/3 filling fraction (FF), 1/3 peak filling rate (PFR) and time to peak filling (TPF). The peak filling rate (PFR) at rest was significantly lower in mild cases (2.4 +/- 0.5 EDV/sec, p less than 0.025). Although the PFR at rest in moderate cases was lower than in negative cases (2.9 +/- 0.6 EDV/sec, 3.2 +/- 0.7 EDV/sec), no significant difference was shown between them. The rate of increase in cardiac output was significantly lower in moderate cases compared to mild cases and negative cases (59 +/- 28%, 96 +/- 49%, 97 +/- 31%, p less than 0.05).(ABSTRACT TRUNCATED AT 400 WORDS)

UI	MeSH Term	Description	Entries
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009200	Myocardial Contraction	Contractile activity of the MYOCARDIUM.	Heart Contractility,Inotropism, Cardiac,Cardiac Inotropism,Cardiac Inotropisms,Contractilities, Heart,Contractility, Heart,Contraction, Myocardial,Contractions, Myocardial,Heart Contractilities,Inotropisms, Cardiac,Myocardial Contractions
D009202	Cardiomyopathies	A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).	Myocardial Disease,Myocardial Diseases,Myocardial Diseases, Primary,Myocardial Diseases, Secondary,Myocardiopathies,Primary Myocardial Disease,Cardiomyopathies, Primary,Cardiomyopathies, Secondary,Primary Myocardial Diseases,Secondary Myocardial Diseases,Cardiomyopathy,Cardiomyopathy, Primary,Cardiomyopathy, Secondary,Disease, Myocardial,Disease, Primary Myocardial,Disease, Secondary Myocardial,Diseases, Myocardial,Diseases, Primary Myocardial,Diseases, Secondary Myocardial,Myocardial Disease, Primary,Myocardial Disease, Secondary,Myocardiopathy,Primary Cardiomyopathies,Primary Cardiomyopathy,Secondary Cardiomyopathies,Secondary Cardiomyopathy,Secondary Myocardial Disease
D011877	Radionuclide Imaging	The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.	Gamma Camera Imaging,Radioisotope Scanning,Scanning, Radioisotope,Scintigraphy,Scintiphotography,Imaging, Gamma Camera,Imaging, Radionuclide
D004452	Echocardiography	Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.	Echocardiography, Contrast,Echocardiography, Cross-Sectional,Echocardiography, M-Mode,Echocardiography, Transthoracic,Echocardiography, Two-Dimensional,Transthoracic Echocardiography,2-D Echocardiography,2D Echocardiography,Contrast Echocardiography,Cross-Sectional Echocardiography,Echocardiography, 2-D,Echocardiography, 2D,M-Mode Echocardiography,Two-Dimensional Echocardiography,2 D Echocardiography,Cross Sectional Echocardiography,Echocardiography, 2 D,Echocardiography, Cross Sectional,Echocardiography, M Mode,Echocardiography, Two Dimensional,M Mode Echocardiography,Two Dimensional Echocardiography
D005082	Physical Exertion	Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.	Physical Effort,Effort, Physical,Efforts, Physical,Exertion, Physical,Exertions, Physical,Physical Efforts,Physical Exertions
D006321	Heart	The hollow, muscular organ that maintains the circulation of the blood.	Hearts
D006352	Heart Ventricles	The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.	Cardiac Ventricle,Cardiac Ventricles,Heart Ventricle,Left Ventricle,Right Ventricle,Left Ventricles,Right Ventricles,Ventricle, Cardiac,Ventricle, Heart,Ventricle, Left,Ventricle, Right,Ventricles, Cardiac,Ventricles, Heart,Ventricles, Left,Ventricles, Right
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults