Biomaterial Database

Mathematical evaluation of 24-hour blood-pressure variability in young, middle-aged and elderly hypertensive patients. 1987

O Tochikubo, and N Miyazaki, and Y Yamada, and M Fukuoka, and Y Kaneko

Second Department of Internal Medicine, Yokohama City University, School of Medicine, Japan.

The characteristics of 24-hour blood pressure variation in hypertensive patients were assessed using new indices of variability. Blood pressure of 43 inpatients with essential hypertension was measured using a portable device without disturbing daily behaviors. Variances in systolic and diastolic pressure values obtained for a day (SDd2), and short-term (SDh2) and long-term (SD24(2) variances were calculated; their relationship was expressed as SDd2 = SDh2 + SD24(2). SDh and SD24 were expedient in assessing the relatively fast and slow blood-pressure variations, respectively. The results showed that the ratio SDh2/SDd2 (percentile of the short-term variance in a whole-day variance) increased and therefore SD24(2)/SDd2 decreased as age increased for both systolic and diastolic pressures. It was found, moreover, that systolic SDh was significantly related to age and baroreflex sensitivity, and systolic SD24 to the heart rate during waking hours. The physiological and clinical significance of SDh and SD24 is discussed, briefly, including arterial wall stiffness.

UI	MeSH Term	Description	Entries
D006973	Hypertension	Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.	Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D008991	Monitoring, Physiologic	The continuous measurement of physiological processes, blood pressure, heart rate, renal output, reflexes, respiration, etc., in a patient or experimental animal; includes pharmacologic monitoring, the measurement of administered drugs or their metabolites in the blood, tissues, or urine.	Patient Monitoring,Monitoring, Physiological,Physiologic Monitoring,Monitoring, Patient,Physiological Monitoring
D011311	Pressoreceptors	Receptors in the vascular system, particularly the aorta and carotid sinus, which are sensitive to stretch of the vessel walls.	Baroreceptors,Receptors, Stretch, Arterial,Receptors, Stretch, Vascular,Stretch Receptors, Arterial,Stretch Receptors, Vascular,Arterial Stretch Receptor,Arterial Stretch Receptors,Baroreceptor,Pressoreceptor,Receptor, Arterial Stretch,Receptor, Vascular Stretch,Receptors, Arterial Stretch,Receptors, Vascular Stretch,Stretch Receptor, Arterial,Stretch Receptor, Vascular,Vascular Stretch Receptor,Vascular Stretch Receptors
D012018	Reflex	An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002940	Circadian Rhythm	The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs or environmental and physiological stimuli.	Diurnal Rhythm,Nyctohemeral Rhythm,Twenty-Four Hour Rhythm,Nycthemeral Rhythm,Circadian Rhythms,Diurnal Rhythms,Nycthemeral Rhythms,Nyctohemeral Rhythms,Rhythm, Circadian,Rhythm, Diurnal,Rhythm, Nycthemeral,Rhythm, Nyctohemeral,Rhythm, Twenty-Four Hour,Rhythms, Circadian,Rhythms, Diurnal,Rhythms, Nycthemeral,Rhythms, Nyctohemeral,Rhythms, Twenty-Four Hour,Twenty Four Hour Rhythm,Twenty-Four Hour Rhythms
D003971	Diastole	Post-systolic relaxation of the HEART, especially the HEART VENTRICLES.	Diastoles
D005260	Female		Females