-transparent.png){kind=logo}
The in vitro effects of obstetric drugs on 15-hydroxyprostaglandin dehydrogenase activity were investigated. Enzyme activity was inhibited by indomethacin, methylergometrine maleate, Solcoseryl, conjugated estrogen and progesterone, and was activated only by isoxsuprine-HCL. Methylergometrine maleate and isoxsuprine-HCl, which have opposite functions on uterine muscle, also exerted contrary effects on enzyme activity. Inhibitory and stimulatory effects of these drugs suggested that they could directly regulate uterine activity and also indirectly influence the uterus due to their effects on prostaglandin catabolism in vivo.
Related Publications
K Nagai, and
T Tanaka, and
K Tsuruta, and
N Mori
March 1972,
Proceedings of the National Academy of Sciences of the United States of America,
K Nagai, and
T Tanaka, and
K Tsuruta, and
N Mori
November 2011,
Prostaglandins & other lipid mediators,
K Nagai, and
T Tanaka, and
K Tsuruta, and
N Mori
January 1976,
Advances in prostaglandin and thromboxane research,
K Nagai, and
T Tanaka, and
K Tsuruta, and
N Mori
October 1995,
Journal of lipid mediators and cell signalling,
K Nagai, and
T Tanaka, and
K Tsuruta, and
N Mori
February 1976,
Biochemical and biophysical research communications,
K Nagai, and
T Tanaka, and
K Tsuruta, and
N Mori
February 2008,
American journal of physiology. Renal physiology,
K Nagai, and
T Tanaka, and
K Tsuruta, and
N Mori
August 1988,
Prostaglandins,
K Nagai, and
T Tanaka, and
K Tsuruta, and
N Mori
January 1988,
European journal of obstetrics, gynecology, and reproductive biology,
K Nagai, and
T Tanaka, and
K Tsuruta, and
N Mori
November 2013,
The international journal of biochemistry & cell biology,
K Nagai, and
T Tanaka, and
K Tsuruta, and
N Mori
February 1978,
Biochemical and biophysical research communications,
