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Various biological activities of amsacrine derivatives were analyzed in relation to various physico-chemical parameters. The in vitro activity parameters like DNA-binding and cell inhibition constants were found to have significant correlations but with varying physico-chemical parameters. DNA-binding constants were found to be the function of van der Waals volume and the cell inhibition constant to be the function of the hydrophobic parameter. But the in vivo antitumor activity parameters like optimal dose administered intraperitoneally in mice injected with P388 leukemia cells and the percentage increase in life span of treated animals over that of control animals were not found to be related with any property of the molecules.
S P Gupta, and
A Ray, and
A Handa, and
Y S Prabhakar, and
D Aggarwal
August 1985,
Il Farmaco; edizione scientifica,
S P Gupta, and
A Ray, and
A Handa, and
Y S Prabhakar, and
D Aggarwal
December 2004,
Journal of molecular modeling,
S P Gupta, and
A Ray, and
A Handa, and
Y S Prabhakar, and
D Aggarwal
March 1987,
Research communications in chemical pathology and pharmacology,
S P Gupta, and
A Ray, and
A Handa, and
Y S Prabhakar, and
D Aggarwal
April 2004,
SAR and QSAR in environmental research,
S P Gupta, and
A Ray, and
A Handa, and
Y S Prabhakar, and
D Aggarwal
January 2015,
Bioorganic & medicinal chemistry letters,
S P Gupta, and
A Ray, and
A Handa, and
Y S Prabhakar, and
D Aggarwal
October 2009,
TheScientificWorldJournal,
S P Gupta, and
A Ray, and
A Handa, and
Y S Prabhakar, and
D Aggarwal
April 2004,
Journal of medicinal chemistry,
S P Gupta, and
A Ray, and
A Handa, and
Y S Prabhakar, and
D Aggarwal
April 1985,
Yao xue xue bao = Acta pharmaceutica Sinica,
S P Gupta, and
A Ray, and
A Handa, and
Y S Prabhakar, and
D Aggarwal
July 1991,
Chemical & pharmaceutical bulletin,
S P Gupta, and
A Ray, and
A Handa, and
Y S Prabhakar, and
D Aggarwal
December 2007,
Chemical biology & drug design,
