| D009124 |
Muscle Proteins |
The protein constituents of muscle, the major ones being ACTINS and MYOSINS. More than a dozen accessory proteins exist including TROPONIN; TROPOMYOSIN; and DYSTROPHIN. |
Muscle Protein,Protein, Muscle,Proteins, Muscle |
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| D002460 |
Cell Line |
Established cell cultures that have the potential to propagate indefinitely. |
Cell Lines,Line, Cell,Lines, Cell |
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| D004268 |
DNA-Binding Proteins |
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. |
DNA Helix Destabilizing Proteins,DNA-Binding Protein,Single-Stranded DNA Binding Proteins,DNA Binding Protein,DNA Single-Stranded Binding Protein,SS DNA BP,Single-Stranded DNA-Binding Protein,Binding Protein, DNA,DNA Binding Proteins,DNA Single Stranded Binding Protein,DNA-Binding Protein, Single-Stranded,Protein, DNA-Binding,Single Stranded DNA Binding Protein,Single Stranded DNA Binding Proteins |
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| D006801 |
Humans |
Members of the species Homo sapiens. |
Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man |
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| D015398 |
Signal Transduction |
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway. |
Cell Signaling,Receptor-Mediated Signal Transduction,Signal Pathways,Receptor Mediated Signal Transduction,Signal Transduction Pathways,Signal Transduction Systems,Pathway, Signal,Pathway, Signal Transduction,Pathways, Signal,Pathways, Signal Transduction,Receptor-Mediated Signal Transductions,Signal Pathway,Signal Transduction Pathway,Signal Transduction System,Signal Transduction, Receptor-Mediated,Signal Transductions,Signal Transductions, Receptor-Mediated,System, Signal Transduction,Systems, Signal Transduction,Transduction, Signal,Transductions, Signal |
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| D042783 |
Endothelial Cells |
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer. |
Capillary Endothelial Cells,Lymphatic Endothelial Cells,Vascular Endothelial Cells,Capillary Endothelial Cell,Cell, Capillary Endothelial,Cell, Endothelial,Cell, Lymphatic Endothelial,Cell, Vascular Endothelial,Cells, Capillary Endothelial,Cells, Endothelial,Cells, Lymphatic Endothelial,Cells, Vascular Endothelial,Endothelial Cell,Endothelial Cell, Capillary,Endothelial Cell, Lymphatic,Endothelial Cell, Vascular,Endothelial Cells, Capillary,Endothelial Cells, Lymphatic,Endothelial Cells, Vascular,Lymphatic Endothelial Cell,Vascular Endothelial Cell |
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| D050778 |
NFATC Transcription Factors |
A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2. |
NFAT Transcription Factor 1,NFAT Transcription Factor 2,NFAT Transcription Factor 3,NFAT Transcription Factor 4,NFAT Transcription Factor 5,Nuclear Factors of Activated T-Cells,NF-AT Proteins,NF-AT3 Protein,NF-AT4 Protein,NF-ATc1 Protein,NFAT Proteins,NFAT-1 Protein,NFAT-2 Protein,NFAT1 Protein,NFAT2 Protein,NFAT3 Protein,NFAT4 Protein,NFAT5 Protein,NFATC Proteins,NFATC1 Protein,NFATC1 Transcription Factor,NFATC2 Protein,NFATC2 Transcription Factor,NFATC3 Protein,NFATC3 Transcription Factor,NFATC4 Protein,NFATC4 Transcription Factor,NFATL1 Protein,NFATx Protein,NFATz Protein,Nuclear Factor of Activated T-Cells 5 Protein,Nuclear Factor of Activated T-Cells, Cytoplasmic,Nuclear Factor of Activated T-Cells, Cytoplasmic 1 Protein,Nuclear Factor of Activated T-Cells, Cytoplasmic 2 Protein,Nuclear Factor of Activated T-Cells, Cytoplasmic 3 Protein,Nuclear Factor of Activated T-Cells, Cytoplasmic 4 Protein,OREBP Protein,Osmotic Response Element Binding Protein,TonEBP Protein,Tonicity-Responsive Enhancer-Binding Protein,Transcription Factor NF-AT,Factor, NFATC1 Transcription,Factor, NFATC2 Transcription,Factor, NFATC3 Transcription,NF AT Proteins,NF AT3 Protein,NF AT4 Protein,NF ATc1 Protein,NF-AT, Transcription Factor,NFAT 1 Protein,NFAT 2 Protein,Nuclear Factor of Activated T Cells 5 Protein,Nuclear Factor of Activated T Cells, Cytoplasmic,Nuclear Factor of Activated T Cells, Cytoplasmic 1 Protein,Nuclear Factor of Activated T Cells, Cytoplasmic 2 Protein,Nuclear Factor of Activated T Cells, Cytoplasmic 3 Protein,Nuclear Factor of Activated T Cells, Cytoplasmic 4 Protein,Nuclear Factors of Activated T Cells,Tonicity Responsive Enhancer Binding Protein,Transcription Factor NF AT,Transcription Factor, NFATC1,Transcription Factor, NFATC2,Transcription Factor, NFATC3,Transcription Factor, NFATC4,Transcription Factors, NFATC |
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| D019703 |
Calcineurin |
A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes. |
Calcineurin A,Calcineurin B,Protein Phosphatase-2B,Protein Phosphatase 3,Protein Phosphatase 3 Catalytic Subunit,Protein Phosphatase 3 Regulatory Subunit,Phosphatase 3, Protein,Protein Phosphatase 2B |
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| D021581 |
Active Transport, Cell Nucleus |
Gated transport mechanisms by which proteins or RNA are moved across the NUCLEAR MEMBRANE. |
Nuclear Export,Nuclear Import,Nuclear Transport,Nucleocytoplasmic Transport,Nucleo-cytoplasmic Transport,Export, Nuclear,Import, Nuclear,Nucleo cytoplasmic Transport,Transport, Nuclear,Transport, Nucleo-cytoplasmic,Transport, Nucleocytoplasmic,Transports, Nucleo-cytoplasmic |
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