Biomaterial Database

Taurine conjugation of bile acids protects human cells in culture. 1987

G E Gaull, and C E Wright

New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314.

The primary trihydroxy bile acid, cholate, both free and conjugated, is nontoxic in cultured human lymphoblastoid cells incubated in vitro. The primary dihydroxy bile acid, chenodeoxycholate, was more toxic at high concentrations than at low concentrations, but conjugation with taurine reversed it. The free secondary bile acids, deoxycholate and lithocholate, corresponding respectively to cholate and chenodeoxycholate, are extremely toxic, the latter more than the former. Conjugation with taurine reversed the toxicity, as did glycine. Neither free taurine nor free glycine added to unconjugated bile acids decreased toxicity.

UI	MeSH Term	Description	Entries
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D002460	Cell Line	Established cell cultures that have the potential to propagate indefinitely.	Cell Lines,Line, Cell,Lines, Cell
D002470	Cell Survival	The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.	Cell Viability,Cell Viabilities,Survival, Cell,Viabilities, Cell,Viability, Cell
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001647	Bile Acids and Salts	Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones.	Bile Acid,Bile Salt,Bile Salts,Bile Acids,Acid, Bile,Acids, Bile,Salt, Bile,Salts, Bile
D013329	Structure-Activity Relationship	The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.	Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships
D013654	Taurine	A conditionally essential nutrient, important during mammalian development. It is present in milk but is isolated mostly from ox bile and strongly conjugates bile acids.	Taufon,Tauphon,Taurine Hydrochloride,Taurine Zinc Salt (2:1),Taurine, Monopotassium Salt