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To clarify the renal function induced by water deprivation-induced dehydration, intrarenal blood flow and changes in adenine nucleotide level in the renal tissue were investigated. Male SD rats were completely deprived of water for 2, 4 and 5 days. The intrarenal blood flow was determined by the hydrogen-gas clearance method and adenine nucleotide level in the renal tissue by high pressure liquid chromatography (HPLC) on the 2nd, 4th, and 5th day after water deprivation. The renal function and energy charge (EC = [ATP + 1/2 ADP]/[ATP + ADP + AMP]) were normal in all rats. In the dehydrated rats, the urine and blood were concentrated, and the medullary blood flow decreased. The mean arterial blood pressure was in the lower limit of renal perfusion pressure under autoregulation. In conclusion, the lower limit of renal perfusion pressure under autoregulation and urine and blood concentration due to water deprivation-induced dehydration may easily cause acute renal failure.
E Ishikawa
January 1988,
Biopharmaceutics & drug disposition,
E Ishikawa
March 1951,
Pediatrics,
E Ishikawa
July 1972,
Morphologiai es igazsagugyi orvosi szemle,
E Ishikawa
January 1968,
Acta physiologica Academiae Scientiarum Hungaricae,
E Ishikawa
January 1980,
Endokrynologia Polska,
E Ishikawa
January 1989,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
E Ishikawa
January 1977,
Folia biologica,
E Ishikawa
January 1984,
Biopharmaceutics & drug disposition,
E Ishikawa
January 1984,
Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury,
E Ishikawa
January 1958,
Acta medica Academiae Scientiarum Hungaricae,
