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The functioning of the hypothalamo-pituitary-target organs axis was assessed in 3 patients with 'fertile eunuch' syndrome (FE) and 6 patients with 'classic' hypogonadotrophic hypogonadism (HH) with or without hyposmia. Both groups of patients did not differ from each other with regard to basal serum prolactin levels, pituitary growth hormone and thyrotrophin reserve and the thyroid or adrenal gland function. Both groups differed, however, with respect to the hypothalamo-pituitary-gonadal function: 1. the pituitary LH response to exogenous LH-RH was (low)-normal in FE and blunted in HH; 2. the basal FSH levels were normal in FE and undetectable in HH; 3. the basal LH levels were normal in FE and 3/6 patients with HH and low in the remaining three; 4. the basal and HCG stimulated plasma testosterone concentrations were significantly higher in FE than HH. The data suggest that FE represents a less severe form of LH-RH deficiency, rather than a distinct disorder.
A G Smals, and
P W Kloppenborg, and
U J van Haelst, and
R Lequin, and
T J Benraad
April 1982,
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris,
A G Smals, and
P W Kloppenborg, and
U J van Haelst, and
R Lequin, and
T J Benraad
January 1993,
Ryoikibetsu shokogun shirizu,
A G Smals, and
P W Kloppenborg, and
U J van Haelst, and
R Lequin, and
T J Benraad
June 2000,
Clinical genetics,
A G Smals, and
P W Kloppenborg, and
U J van Haelst, and
R Lequin, and
T J Benraad
March 1977,
British medical journal,
A G Smals, and
P W Kloppenborg, and
U J van Haelst, and
R Lequin, and
T J Benraad
January 1977,
British medical journal,
A G Smals, and
P W Kloppenborg, and
U J van Haelst, and
R Lequin, and
T J Benraad
September 1961,
Annals of internal medicine,
A G Smals, and
P W Kloppenborg, and
U J van Haelst, and
R Lequin, and
T J Benraad
January 2022,
Frontiers in endocrinology,
A G Smals, and
P W Kloppenborg, and
U J van Haelst, and
R Lequin, and
T J Benraad
October 1976,
Dermatologische Monatschrift,
A G Smals, and
P W Kloppenborg, and
U J van Haelst, and
R Lequin, and
T J Benraad
January 1989,
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A G Smals, and
P W Kloppenborg, and
U J van Haelst, and
R Lequin, and
T J Benraad
February 1982,
The Practitioner,
