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New side chain-modified iodothyronines have been synthesized. They include: 1-[4-(4-hydroxyphenoxy)-3,5-diiodophenyl]-1,2-ethanediol (T2EG); alpha-hydroxy-4-(4-hydroxyphenoxy)-3,5-diiodobenzeneacetic acid (T2HAA) and their 4-methyl ether derivatives (MT2EG, MT2HAA); 1-[4-(4-hydroxyphenoxy)-3,5-diiodophenyl]-2-aminoethanol (T2EA); 1-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-1,2-ethaned iol (T3EG); 1-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-aminoetha nol (T3EA); and alpha-hydroxy-4-(3-iodo-4-hydroxyphenoxy)-3,5-diiodobenzeneacet ic acid (T3HAA). These model compounds are being used to study thyroid hormone metabolism and to determine structure-activity relationships of iododiphenylether derivatives.
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