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Whole blood serotonin and tryptophan were measured in 87 normal subjects and in 40 autistic subjects. Whole blood serotonin concentrations (mean +/- SE) were significantly higher in drug-free (N = 21) autistics (205 +/- 16 ng/ml) than in normals (136 +/- 5.4 ng/ml). The Gaussian distribution of serotonin levels in the unmedicated autistic group suggests the elevation was not due to a subgroup of autistic subjects. Autistics medicated with anticonvulsants or neuroleptics had significantly lower serotonin levels than did drug-free autistic subjects. Whole blood tryptophan levels and platelet counts were similar in the autistic and normal groups. The possible causes of the hyperserotonemia of autism are discussed.
G M Anderson, and
D X Freedman, and
D J Cohen, and
F R Volkmar, and
E L Hoder, and
P McPhedran, and
R B Minderaa, and
C R Hansen, and
J G Young
August 1987,
Biological psychiatry,
G M Anderson, and
D X Freedman, and
D J Cohen, and
F R Volkmar, and
E L Hoder, and
P McPhedran, and
R B Minderaa, and
C R Hansen, and
J G Young
January 1993,
The Journal of neuropsychiatry and clinical neurosciences,
G M Anderson, and
D X Freedman, and
D J Cohen, and
F R Volkmar, and
E L Hoder, and
P McPhedran, and
R B Minderaa, and
C R Hansen, and
J G Young
October 1974,
Folia endocrinologica,
G M Anderson, and
D X Freedman, and
D J Cohen, and
F R Volkmar, and
E L Hoder, and
P McPhedran, and
R B Minderaa, and
C R Hansen, and
J G Young
January 1999,
Biological psychiatry,
G M Anderson, and
D X Freedman, and
D J Cohen, and
F R Volkmar, and
E L Hoder, and
P McPhedran, and
R B Minderaa, and
C R Hansen, and
J G Young
January 1971,
Acta anaesthesiologica Scandinavica. Supplementum,
G M Anderson, and
D X Freedman, and
D J Cohen, and
F R Volkmar, and
E L Hoder, and
P McPhedran, and
R B Minderaa, and
C R Hansen, and
J G Young
March 1993,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
G M Anderson, and
D X Freedman, and
D J Cohen, and
F R Volkmar, and
E L Hoder, and
P McPhedran, and
R B Minderaa, and
C R Hansen, and
J G Young
March 1988,
Journal of autism and developmental disorders,
G M Anderson, and
D X Freedman, and
D J Cohen, and
F R Volkmar, and
E L Hoder, and
P McPhedran, and
R B Minderaa, and
C R Hansen, and
J G Young
January 1984,
Neuropsychobiology,
G M Anderson, and
D X Freedman, and
D J Cohen, and
F R Volkmar, and
E L Hoder, and
P McPhedran, and
R B Minderaa, and
C R Hansen, and
J G Young
March 1986,
The Journal of pediatrics,
G M Anderson, and
D X Freedman, and
D J Cohen, and
F R Volkmar, and
E L Hoder, and
P McPhedran, and
R B Minderaa, and
C R Hansen, and
J G Young
March 1989,
Journal of the American Academy of Child and Adolescent Psychiatry,
