Influence of bradykinin on blood pressure regulation of spontaneously hypertensive rats maintained on different sodium intakes. 1987

B Waeber, and J F Aubert, and J Nussberger, and R Vavrek, and J M Stewart, and H R Brunner
Division of Hypertension, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

1. The role of circulating bradykinin in blood pressure regulation was studied in conscious spontaneously hypertensive rats utilizing the competitive antagonist of bradykinin B4162. 2. This antagonist was administered at a bolus dose (400 micrograms i.v.) known to block the hypotensive effect of exogenous bradykinin for at least 2 min. The rats were maintained for 10 days either on a low or a high sodium intake. 3. The antagonist of bradykinin significantly increased blood pressure only in salt-depleted rats. In other rats kept on a low or a high sodium intake, dose-response curves to exogenous bradykinin were established. Dietary sodium had no influence on the blood pressure-lowering effect of bradykinin. 4. These data therefore suggest that circulating bradykinin may be involved in the blood pressure control of spontaneously hypertensive rats when the renin-angiotensin system is stimulated by salt depletion.

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D008297 Male Males
D009842 Oligopeptides Peptides composed of between two and twelve amino acids. Oligopeptide
D011918 Rats, Inbred SHR A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke. Rats, Spontaneously Hypertensive,Rats, SHR,Inbred SHR Rat,Inbred SHR Rats,Rat, Inbred SHR,Rat, SHR,Rat, Spontaneously Hypertensive,SHR Rat,SHR Rat, Inbred,SHR Rats,SHR Rats, Inbred,Spontaneously Hypertensive Rat,Spontaneously Hypertensive Rats
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D001920 Bradykinin A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from MAST CELLS during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter. Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg,Bradykinin Acetate, (9-D-Arg)-Isomer,Bradykinin Diacetate,Bradykinin Hydrochloride,Bradykinin Triacetate,Bradykinin, (1-D-Arg)-Isomer,Bradykinin, (2-D-Pro)-Isomer,Bradykinin, (2-D-Pro-3-D-Pro-7-D-Pro)-Isomer,Bradykinin, (2-D-Pro-7-D-Pro)-Isomer,Bradykinin, (3-D-Pro)-Isomer,Bradykinin, (3-D-Pro-7-D-Pro)-Isomer,Bradykinin, (5-D-Phe)-Isomer,Bradykinin, (5-D-Phe-8-D-Phe)-Isomer,Bradykinin, (6-D-Ser)-Isomer,Bradykinin, (7-D-Pro)-Isomer,Bradykinin, (8-D-Phe)-Isomer,Bradykinin, (9-D-Arg)-Isomer,Arg Pro Pro Gly Phe Ser Pro Phe Arg
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012982 Sodium, Dietary Sodium or sodium compounds used in foods or as a food. The most frequently used compounds are sodium chloride or sodium glutamate. Dietary Sodium
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D066298 In Vitro Techniques Methods to study reactions or processes taking place in an artificial environment outside the living organism. In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In

Related Publications

B Waeber, and J F Aubert, and J Nussberger, and R Vavrek, and J M Stewart, and H R Brunner
February 1995, Hypertension (Dallas, Tex. : 1979),
B Waeber, and J F Aubert, and J Nussberger, and R Vavrek, and J M Stewart, and H R Brunner
April 1999, British journal of pharmacology,
B Waeber, and J F Aubert, and J Nussberger, and R Vavrek, and J M Stewart, and H R Brunner
January 2011, Neuroscience letters,
B Waeber, and J F Aubert, and J Nussberger, and R Vavrek, and J M Stewart, and H R Brunner
July 1992, Contraception,
B Waeber, and J F Aubert, and J Nussberger, and R Vavrek, and J M Stewart, and H R Brunner
July 1975, Experientia,
B Waeber, and J F Aubert, and J Nussberger, and R Vavrek, and J M Stewart, and H R Brunner
August 1996, British journal of pharmacology,
B Waeber, and J F Aubert, and J Nussberger, and R Vavrek, and J M Stewart, and H R Brunner
May 1969, Japanese circulation journal,
B Waeber, and J F Aubert, and J Nussberger, and R Vavrek, and J M Stewart, and H R Brunner
January 1979, Advances in experimental medicine and biology,
B Waeber, and J F Aubert, and J Nussberger, and R Vavrek, and J M Stewart, and H R Brunner
January 1989, Clinical and experimental hypertension. Part A, Theory and practice,
B Waeber, and J F Aubert, and J Nussberger, and R Vavrek, and J M Stewart, and H R Brunner
June 1988, Clinical science (London, England : 1979),
Copied contents to your clipboard!