Pathologic Characterization of Coinfection with Histomonas meleagridis, Marek's Disease Virus, and Subtype J Avian Leukosis Virus in Chickens. 2021

Ming Li, and Haifeng Xiong, and Hanwen Wu, and Dongmei Hu, and Yan Lin, and Xueting Huang, and Jun Wang, and Kezong Qi, and Hongmei Liu
Anhui Province Key Laboratory of Veterinary Pathobiology and Disease Control, Anhui Agricultural University, Hefei, Anhui, China.

Histomonas meleagridis is a trichomonad protozoan parasite that can cause an important poultry disease known as histomoniasis; Marek's disease virus (MDV) and subtype J avian leukosis virus (ALV-J) usually cause avian oncogenic diseases. Although these diseases have been reported in a single pathogen infection, information about their coinfection is scarce. This study reports a naturally occurring case of coinfection with H. meleagridis, MDV, and ALV-J in a local chicken flock at the age of 150 days. Necropsy revealed necrosis and swelling in the liver and spleen. Histologic analysis showed large areas of mild to severe necrosis of hepatocytes, with numerous intralesional trophozoites of H. meleagridis by H&E and periodic acid-Schiff staining; H&E staining showed pleomorphic and neoplastic lymphoid tumor cells in the liver and myeloid cells with eosinophilic cytoplasmic granules in the spleen. Coexpression of MDV and ALV-J antigens was detected in the liver by fluorescence multiplex immunohistochemistry staining. The 18S rRNA gene of H. meleagridis, meq gene of MDV, and gp85 gene of ALV-J were identified in mixed liver and spleen tissues by PCR and sequencing, respectively.

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008380 Marek Disease A transmissible viral disease of birds caused by avian herpesvirus 2 (HERPESVIRUS 2, GALLID) and other MARDIVIRUS. There is lymphoid cell infiltration or lymphomatous tumor formation in the peripheral nerves and gonads, but may also involve visceral organs, skin, muscle, and the eye. Fowl Paralysis,Marek's Disease,Fowl Paralyses,Mareks Disease,Paralyses, Fowl,Paralysis, Fowl
D010802 Phylogeny The relationships of groups of organisms as reflected by their genetic makeup. Community Phylogenetics,Molecular Phylogenetics,Phylogenetic Analyses,Phylogenetic Analysis,Phylogenetic Clustering,Phylogenetic Comparative Analysis,Phylogenetic Comparative Methods,Phylogenetic Distance,Phylogenetic Generalized Least Squares,Phylogenetic Groups,Phylogenetic Incongruence,Phylogenetic Inference,Phylogenetic Networks,Phylogenetic Reconstruction,Phylogenetic Relatedness,Phylogenetic Relationships,Phylogenetic Signal,Phylogenetic Structure,Phylogenetic Tree,Phylogenetic Trees,Phylogenomics,Analyse, Phylogenetic,Analysis, Phylogenetic,Analysis, Phylogenetic Comparative,Clustering, Phylogenetic,Community Phylogenetic,Comparative Analysis, Phylogenetic,Comparative Method, Phylogenetic,Distance, Phylogenetic,Group, Phylogenetic,Incongruence, Phylogenetic,Inference, Phylogenetic,Method, Phylogenetic Comparative,Molecular Phylogenetic,Network, Phylogenetic,Phylogenetic Analyse,Phylogenetic Clusterings,Phylogenetic Comparative Analyses,Phylogenetic Comparative Method,Phylogenetic Distances,Phylogenetic Group,Phylogenetic Incongruences,Phylogenetic Inferences,Phylogenetic Network,Phylogenetic Reconstructions,Phylogenetic Relatednesses,Phylogenetic Relationship,Phylogenetic Signals,Phylogenetic Structures,Phylogenetic, Community,Phylogenetic, Molecular,Phylogenies,Phylogenomic,Reconstruction, Phylogenetic,Relatedness, Phylogenetic,Relationship, Phylogenetic,Signal, Phylogenetic,Structure, Phylogenetic,Tree, Phylogenetic
D011201 Poultry Diseases Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild. Disease, Poultry,Diseases, Poultry,Poultry Disease
D011528 Protozoan Infections Infections with unicellular organisms formerly members of the subkingdom Protozoa. Histomoniasis,Infections, Protozoan,Histomoniases,Infection, Protozoan,Protozoan Infection
D002645 Chickens Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA. Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001353 Avian Leukosis A group of transmissible viral diseases of chickens and turkeys. Liver tumors are found in most forms, but tumors can be found elsewhere. Leukosis, Avian,Avian Leukoses,Leukoses, Avian
D001354 Avian Leukosis Virus The type species of ALPHARETROVIRUS producing latent or manifest lymphoid leukosis in fowl. Leukosis Virus, Avian,Lymphomatosis Virus, Avian,Rous-Associated Virus,Avian Leukosis Viruses,Avian Lymphomatosis Virus,Avian Lymphomatosis Viruses,Leukosis Viruses, Avian,Lymphomatosis Viruses, Avian,Rous Associated Virus,Virus, Avian Leukosis,Virus, Avian Lymphomatosis,Virus, Rous-Associated,Viruses, Avian Leukosis,Viruses, Avian Lymphomatosis
D013154 Spleen An encapsulated lymphatic organ through which venous blood filters.

Related Publications

Ming Li, and Haifeng Xiong, and Hanwen Wu, and Dongmei Hu, and Yan Lin, and Xueting Huang, and Jun Wang, and Kezong Qi, and Hongmei Liu
June 2006, Avian diseases,
Ming Li, and Haifeng Xiong, and Hanwen Wu, and Dongmei Hu, and Yan Lin, and Xueting Huang, and Jun Wang, and Kezong Qi, and Hongmei Liu
September 2019, Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc,
Ming Li, and Haifeng Xiong, and Hanwen Wu, and Dongmei Hu, and Yan Lin, and Xueting Huang, and Jun Wang, and Kezong Qi, and Hongmei Liu
February 2005, Avian pathology : journal of the W.V.P.A,
Ming Li, and Haifeng Xiong, and Hanwen Wu, and Dongmei Hu, and Yan Lin, and Xueting Huang, and Jun Wang, and Kezong Qi, and Hongmei Liu
November 2009, Bing du xue bao = Chinese journal of virology,
Ming Li, and Haifeng Xiong, and Hanwen Wu, and Dongmei Hu, and Yan Lin, and Xueting Huang, and Jun Wang, and Kezong Qi, and Hongmei Liu
May 2024, Poultry science,
Ming Li, and Haifeng Xiong, and Hanwen Wu, and Dongmei Hu, and Yan Lin, and Xueting Huang, and Jun Wang, and Kezong Qi, and Hongmei Liu
February 2018, Virology journal,
Ming Li, and Haifeng Xiong, and Hanwen Wu, and Dongmei Hu, and Yan Lin, and Xueting Huang, and Jun Wang, and Kezong Qi, and Hongmei Liu
March 2004, Journal of veterinary science,
Ming Li, and Haifeng Xiong, and Hanwen Wu, and Dongmei Hu, and Yan Lin, and Xueting Huang, and Jun Wang, and Kezong Qi, and Hongmei Liu
October 2010, Emerging infectious diseases,
Ming Li, and Haifeng Xiong, and Hanwen Wu, and Dongmei Hu, and Yan Lin, and Xueting Huang, and Jun Wang, and Kezong Qi, and Hongmei Liu
December 2003, Journal of veterinary science,
Ming Li, and Haifeng Xiong, and Hanwen Wu, and Dongmei Hu, and Yan Lin, and Xueting Huang, and Jun Wang, and Kezong Qi, and Hongmei Liu
January 1978, Intervirology,
Copied contents to your clipboard!