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When heat-killed Propionibacterium acnes (P. acnes) and a small amount of endotoxin lipopolysaccharide (LPS) were intravenously injected into mice at a week's interval, most of them died of massive hepatic cell necrosis. This experimentally-induced acute liver injury was significantly inhibited by cyclosporin A (CsA), resulting in a remarkable improvement of the survival rate. This protective effect of CsA on acute liver injury was also histopathologically confirmed. To study the mechanism by which CsA protected the mice from fatal hepatic injury, adherent cells prepared from the murine liver 7 days after P. acnes injection were incubated with LPS in the presence of CsA, and the effect of CsA on the production of the cytotoxic factor from the adherent cells was estimated. As a result, CsA inhibited the activation of liver adherent cells and suppressed the release of the cytotoxic factor.
Y Mizoguchi, and
H Kuboi, and
C Kodama, and
Y Sakagami, and
S Seki, and
K Kobayashi, and
S Yamamoto, and
S Morisawa
March 1987,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
Y Mizoguchi, and
H Kuboi, and
C Kodama, and
Y Sakagami, and
S Seki, and
K Kobayashi, and
S Yamamoto, and
S Morisawa
January 2015,
Gastroenterology research and practice,
Y Mizoguchi, and
H Kuboi, and
C Kodama, and
Y Sakagami, and
S Seki, and
K Kobayashi, and
S Yamamoto, and
S Morisawa
April 1997,
Liver,
Y Mizoguchi, and
H Kuboi, and
C Kodama, and
Y Sakagami, and
S Seki, and
K Kobayashi, and
S Yamamoto, and
S Morisawa
May 2018,
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology,
Y Mizoguchi, and
H Kuboi, and
C Kodama, and
Y Sakagami, and
S Seki, and
K Kobayashi, and
S Yamamoto, and
S Morisawa
December 2001,
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials,
Y Mizoguchi, and
H Kuboi, and
C Kodama, and
Y Sakagami, and
S Seki, and
K Kobayashi, and
S Yamamoto, and
S Morisawa
August 2001,
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials,
Y Mizoguchi, and
H Kuboi, and
C Kodama, and
Y Sakagami, and
S Seki, and
K Kobayashi, and
S Yamamoto, and
S Morisawa
November 2001,
Bioscience, biotechnology, and biochemistry,
Y Mizoguchi, and
H Kuboi, and
C Kodama, and
Y Sakagami, and
S Seki, and
K Kobayashi, and
S Yamamoto, and
S Morisawa
January 2014,
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine,
Y Mizoguchi, and
H Kuboi, and
C Kodama, and
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S Seki, and
K Kobayashi, and
S Yamamoto, and
S Morisawa
January 2008,
Journal of pharmacological sciences,
Y Mizoguchi, and
H Kuboi, and
C Kodama, and
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S Seki, and
K Kobayashi, and
S Yamamoto, and
S Morisawa
January 2006,
Annals of clinical and laboratory science,
