BIOMAT Database Logo BIOMAT Database Logo

Excretion of flurbiprofen into breast milk. 1987

S R Cox, and K K Forbes
Pharmacokinetic/Pharmacodynamic Research Unit, Upjohn Company, Kalamazoo, Michigan 49001.

The extent of flurbiprofen's excretion into mature (postcolostrum) breast milk was evaluated in 10 healthy, nursing mothers after administration of a single 100-mg tablet. Samples of milk and blood were subsequently obtained over a 48-hour period and assayed for flurbiprofen by high-performance liquid chromatography. The average peak plasma flurbiprofen concentration, 15 micrograms/ml, occurred at 1.5 hours, and the harmonic mean half-life of the drug was 5.8 hours. The average peak milk concentration of flurbiprofen was 0.09 microgram/ml, and the maximum recovery of the dose in breast milk was only 0.07%.

UI MeSH Term Description Entries
D008895 Milk, Human Milk that is produced by HUMAN MAMMARY GLANDS. Breast Milk,Human Milk,Milk, Breast
D011422 Propionates Derivatives of propionic acid. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxyethane structure. Propanoate,Propanoic Acid,Propionate,Propanoates,Propanoic Acid Derivatives,Propanoic Acids,Propionic Acid Derivatives,Propionic Acids,Acid, Propanoic,Acids, Propanoic,Acids, Propionic,Derivatives, Propanoic Acid,Derivatives, Propionic Acid
D002851 Chromatography, High Pressure Liquid Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed. Chromatography, High Performance Liquid,Chromatography, High Speed Liquid,Chromatography, Liquid, High Pressure,HPLC,High Performance Liquid Chromatography,High-Performance Liquid Chromatography,UPLC,Ultra Performance Liquid Chromatography,Chromatography, High-Performance Liquid,High-Performance Liquid Chromatographies,Liquid Chromatography, High-Performance
D005260 Female Females
D005480 Flurbiprofen An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE. 2-Fluoro-alpha-methyl-(1,1'-biphenyl)-4-acetic Acid,Ansaid,Apo-Flurbiprofen,BTS-18322,Cebutid,Dobrofen,E-7869,Flubiprofen,Flugalin,Flurbiprofen Sodium,Fluriproben,Froben,Froben SR,Neo Artrol,Novo-Flurprofen,Nu-Flurbiprofen,Ocufen,Ocuflur,Strefen,ratio-Flurbiprofen,Apo Flurbiprofen,BTS 18322,BTS18322,E 7869,E7869,Novo Flurprofen,Nu Flurbiprofen,ratio Flurbiprofen
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

S R Cox, and K K Forbes
Terbutaline excretion into breast milk.
May 1982, British journal of clinical pharmacology,
S R Cox, and K K Forbes
Cyclosporine excretion into breast milk.
June 2003, Transplantation,
S R Cox, and K K Forbes
Metoprolol excretion into breast milk.
May 1980, British journal of clinical pharmacology,
S R Cox, and K K Forbes
Cimetidine excretion into breast milk.
June 1979, British journal of clinical pharmacology,
S R Cox, and K K Forbes
Excretion of fluvoxamine into breast milk.
March 2000, British journal of clinical pharmacology,
S R Cox, and K K Forbes
Excretion of platinum into breast milk.
March 1989, Lancet (London, England),
S R Cox, and K K Forbes
Excretion of ibuprofen into breast milk.
May 1984, American journal of obstetrics and gynecology,
S R Cox, and K K Forbes
Excretion of radiopharmaceuticals into breast milk.
September 1994, European journal of nuclear medicine,
S R Cox, and K K Forbes
Excretion of fluorescein into breast milk.
May 1990, American journal of ophthalmology,
S R Cox, and K K Forbes
Excretion of lorazepam into breast milk.
October 1985, British journal of anaesthesia,
Copied contents to your clipboard!