Biomaterial Database

[Effect of cholesterol and bile acids on ubiquinone metabolism in the body]. 1987

V V Fedurov

Rate of degradation and half-life of ubiquinone were studied in tissues of rats, maintained on standard and artificial diet, which included either cholesterol or bile acids. Metabolism of ubiquinone was distinctly accelerated in liver, kidney tissues and skeletal muscles and was decreased in small intestine of the animals kept on the artificial cholesterol-free diet. After addition of 2% cholesterol to the ration metabolism of ubiquinone was decreased in skeletal muscles and, especially, in liver tissue. When 0.2% bile acids were included into the ration. metabolism of ubiquinone was decreased more than 13-fold in liver tissue, whereas in small intestine it was accelerated and approached the values corresponding to those of control animals.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D002791	Cholesterol, Dietary	Cholesterol present in food, especially in animal products.	Dietary Cholesterol
D004032	Diet	Regular course of eating and drinking adopted by a person or animal.	Diets
D006207	Half-Life	The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.	Halflife,Half Life,Half-Lifes,Halflifes
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001647	Bile Acids and Salts	Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones.	Bile Acid,Bile Salt,Bile Salts,Bile Acids,Acid, Bile,Acids, Bile,Salt, Bile,Salts, Bile
D014018	Tissue Distribution	Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.	Distribution, Tissue,Distributions, Tissue,Tissue Distributions
D014451	Ubiquinone	A lipid-soluble benzoquinone which is involved in ELECTRON TRANSPORT in mitochondrial preparations. The compound occurs in the majority of aerobic organisms, from bacteria to higher plants and animals.	Coenzyme Q
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus