-transparent.png){kind=logo}
The influence of ageing on demethylation of 14C-aminopyrine (AP) and 14C-caffeine (Caf) in Wistar littermate rats was studied serially using the 14CO2-breath test. In both sexes, the elimination half-life (t1/2) of 14C-AP fell from a mean of approximately 75 min when weaned at 17 days to 45 min at maturity (49 days); thereafter t1/2 became prolonged, being most prolonged (82 min) in elderly male rats (210 days). Similarly, t1/2 of 14C-Caf was also prolonged with ageing. These studies using in vivo and longitudinal techniques indicate the importance of ageing on hepatic demethylation.
Related Publications
J Feely, and
P Kelleher, and
A Odumosu
August 1986,
Clinical pharmacology and therapeutics,
J Feely, and
P Kelleher, and
A Odumosu
August 1975,
Gastroenterology,
J Feely, and
P Kelleher, and
A Odumosu
January 1994,
The Italian journal of gastroenterology,
J Feely, and
P Kelleher, and
A Odumosu
March 1979,
Research communications in chemical pathology and pharmacology,
J Feely, and
P Kelleher, and
A Odumosu
September 1985,
Digestive diseases and sciences,
J Feely, and
P Kelleher, and
A Odumosu
April 2014,
Liver international : official journal of the International Association for the Study of the Liver,
J Feely, and
P Kelleher, and
A Odumosu
June 2002,
Isotopes in environmental and health studies,
J Feely, and
P Kelleher, and
A Odumosu
January 1985,
Hepatology (Baltimore, Md.),
J Feely, and
P Kelleher, and
A Odumosu
November 1994,
The Australian and New Zealand journal of surgery,
J Feely, and
P Kelleher, and
A Odumosu
January 1994,
Life sciences,
