-transparent.png){kind=logo}
Synthesis, Characterization, and Biological Evaluation of Some Novel Pyrazolo[5,1-b]thiazole Derivatives as Potential Antimicrobial and Anticancer Agents. 2021
Abdulrhman Alsayari, and
Abdullatif Bin Muhsinah, and
Yahya I Asiri, and
Faiz A Al-Aizari, and
Nabila A Kheder, and
Zainab M Almarhoon, and
Hazem A Ghabbour, and
Yahia N Mabkhot
Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia.
The pharmacological activities of thiazole and pyrazole moieties as antimicrobial and anticancer agents have been thoroughly described in many literature reviews. In this study, a convenient synthesis of novel pyrazolo[5,1-b]thiazole-based heterocycles was carried out. The synthesized compounds were characterized by IR, 1H and 13C NMR spectroscopy and mass spectrometry. Some selected examples were screened and evaluated for their antimicrobial and anticancer activities and showed promising results. These products could serve as leading compounds in the future design of new drug molecules.
Related Publications
Abdulrhman Alsayari, and
Abdullatif Bin Muhsinah, and
Yahya I Asiri, and
Faiz A Al-Aizari, and
Nabila A Kheder, and
Zainab M Almarhoon, and
Hazem A Ghabbour, and
Yahia N Mabkhot
July 2008,
Archiv der Pharmazie,
Abdulrhman Alsayari, and
Abdullatif Bin Muhsinah, and
Yahya I Asiri, and
Faiz A Al-Aizari, and
Nabila A Kheder, and
Zainab M Almarhoon, and
Hazem A Ghabbour, and
Yahia N Mabkhot
February 2019,
Molecules (Basel, Switzerland),
Abdulrhman Alsayari, and
Abdullatif Bin Muhsinah, and
Yahya I Asiri, and
Faiz A Al-Aizari, and
Nabila A Kheder, and
Zainab M Almarhoon, and
Hazem A Ghabbour, and
Yahia N Mabkhot
November 2018,
Molecules (Basel, Switzerland),
Abdulrhman Alsayari, and
Abdullatif Bin Muhsinah, and
Yahya I Asiri, and
Faiz A Al-Aizari, and
Nabila A Kheder, and
Zainab M Almarhoon, and
Hazem A Ghabbour, and
Yahia N Mabkhot
May 2009,
Archiv der Pharmazie,
Abdulrhman Alsayari, and
Abdullatif Bin Muhsinah, and
Yahya I Asiri, and
Faiz A Al-Aizari, and
Nabila A Kheder, and
Zainab M Almarhoon, and
Hazem A Ghabbour, and
Yahia N Mabkhot
July 2021,
Molecules (Basel, Switzerland),
Abdulrhman Alsayari, and
Abdullatif Bin Muhsinah, and
Yahya I Asiri, and
Faiz A Al-Aizari, and
Nabila A Kheder, and
Zainab M Almarhoon, and
Hazem A Ghabbour, and
Yahia N Mabkhot
August 2016,
Bioorganic chemistry,
Abdulrhman Alsayari, and
Abdullatif Bin Muhsinah, and
Yahya I Asiri, and
Faiz A Al-Aizari, and
Nabila A Kheder, and
Zainab M Almarhoon, and
Hazem A Ghabbour, and
Yahia N Mabkhot
October 2004,
Bollettino chimico farmaceutico,
Abdulrhman Alsayari, and
Abdullatif Bin Muhsinah, and
Yahya I Asiri, and
Faiz A Al-Aizari, and
Nabila A Kheder, and
Zainab M Almarhoon, and
Hazem A Ghabbour, and
Yahia N Mabkhot
January 2007,
Arzneimittel-Forschung,
Abdulrhman Alsayari, and
Abdullatif Bin Muhsinah, and
Yahya I Asiri, and
Faiz A Al-Aizari, and
Nabila A Kheder, and
Zainab M Almarhoon, and
Hazem A Ghabbour, and
Yahia N Mabkhot
April 2010,
European journal of medicinal chemistry,
Abdulrhman Alsayari, and
Abdullatif Bin Muhsinah, and
Yahya I Asiri, and
Faiz A Al-Aizari, and
Nabila A Kheder, and
Zainab M Almarhoon, and
Hazem A Ghabbour, and
Yahia N Mabkhot
March 2006,
Bioorganic & medicinal chemistry,
