[Effects of overall food restriction on embryo-fetal development in the rat]. 1987

A Pascalon, and M Bertrand
Laboratoire de Pathologie de la Reproduction, Ecole Nationale Vétérinaire de Lyon, Charbonnières, France.

The effects of different levels of food restriction on the fetal-embryo development have been tested in rats (Sprague Dawley) weighing 250 g. Experimental groups received 100 (control), 75, 50 or 25% of mean daily consumed food containing 17% of proteins, either from the coupling (Day 1) or from the nestling (Day 6) and till the sacrifice (Day 21). The weight of the mothers and the fetus is diminished in function of the degree and the duration of the food restriction. The study of the maternal growth shows an adaptation to the food restriction as well as the pregnancy anabolism. The last one is not observed in the females presenting an early embryonic mortality. The nestling is not affected in any of the groups and the embryonic mortality is only observed at the highest restricted level in 1/10 female restricted from Day 6 on and in 5/10 of the rats restricted from Day 1 on. In these last ones, the emaciation between Day 1 and Day 21 after hysterectomy is 37% and the growth of the surviving fetuses is only 40% of the controls. Embryonic mortality most often precocious (before the 10th Day) shows a phenomenon of "all or none" and touches the entire litter of the females concerned; the others maintain a normal pregnancy. The fetal growth seems privileged as compared with the maternal growth. These restrictions have neither influenced the sex ratio, nor induced any specific teratogenic effect: the delayed ossification seems to be expressed precociously on the 5th sternebra.

UI MeSH Term Description Entries
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011270 Pregnancy, Animal The process of bearing developing young (EMBRYOS or FETUSES) in utero in non-human mammals, beginning from FERTILIZATION to BIRTH. Animal Pregnancies,Animal Pregnancy,Pregnancies, Animal
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D005260 Female Females
D005314 Embryonic and Fetal Development Morphological and physiological development of EMBRYOS or FETUSES. Embryo and Fetal Development,Prenatal Programming,Programming, Prenatal
D005508 Food Deprivation The withholding of food in a structured experimental situation. Deprivation, Food,Deprivations, Food,Food Deprivations
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000824 Animal Nutritional Physiological Phenomena Nutritional physiology of animals. Animal Nutrition Physiology,Animal Nutritional Physiology Phenomena,Animal Nutritional Physiological Phenomenon,Animal Nutritional Physiology,Animal Nutritional Physiology Phenomenon,Veterinary Nutritional Physiology,Nutrition Physiologies, Animal,Nutrition Physiology, Animal,Nutritional Physiology, Animal,Nutritional Physiology, Veterinary,Physiology, Animal Nutrition,Physiology, Animal Nutritional,Physiology, Veterinary Nutritional
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

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