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The need to overcome ever-increasing cases of antifungal resistance and circumvent side effects and drug interactions related to currently available drugs has impelled the demand to expedite the drug discovery and the development of novel antifungals. 1,4-disubstituted 1,2,3-triazole has gained tremendous interest in the last two decades mainly because of its ease of synthesis via copper( I)-catalyzed azide-alkyne cycloaddition (CuAAC) and its broad spectrum of chemotherapeutic potential. 1,2,3-Triazole is an excellent pharmacophore that has been used as a bioisostere for obtaining libraries of new medicinally important scaffolds. The present review focuses on the recent advances (2016-2021) in 1,2,3-triazole derivatives obtained by CuAAC as potential antifungal agents that may facilitate the triazole-based antifungal development process.
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