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Iron-Catalyzed Alkyne-Based Multicomponent Synthesis of Pyrimidines under Air. 2021

Rakesh Mondal, and Gargi Chakraborty, and Amit Kumar Guin, and Susmita Sarkar, and Nanda D Paul
Department of Chemistry, Indian Institute of Engineering Science and Technology, Shibpur, Botanic Garden, Howrah 711103, India.

An iron-catalyzed sustainable, economically affordable, and eco-friendly synthetic protocol for the construction of various trisubstituted pyrimidines is described. A wide range of trisubstituted pyrimidines were prepared using a well-defined, easy to prepare, bench-stable, and phosphine-free iron catalyst featuring a redox-noninnocent tridentate arylazo pincer under comparatively mild aerobic conditions via dehydrogenative functionalization of alcohols with alkynes and amidines.

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