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We studied degranulation of human basophils (HBDT), lymphoblast transformation and leucocyte migration in 8 cases of patients who were sensitive to penicillin (type 1 hypersensitization of the Gell and Coombes classification). The HBDT was negative in 7 of the cases, whilst the lymphoblast transformation and leucocyte migration tests were positive in 6 cases and negative in 2. These latter tests are more efficient than HBDT in the detection of human sensitization to penicillin.
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