BIOMAT Database Logo BIOMAT Database Logo

Pharmacokinetic properties of a novel formulation of S-adenosyl-L-methionine phytate. 2021

Antonio Francioso, and Sergio Fanelli, and Maria d'Erme, and Eugenio Lendaro, and Niccolò Miraglia, and Mario Fontana, and Rosaria A Cavallaro, and Luciana Mosca
Department of Biochemical Sciences A. Rossi Fanelli, Sapienza University, Rome, Italy. antonio.francioso@uniroma1.it.

S-adenosyl-L-methionine (SAM), the main endogenous methyl donor, is the adenosyl derivative of the amino acid methionine, which displays many important roles in cellular metabolism. It is widely used as a food supplement and in some countries is also marketed as a drug. Its interesting nutraceutical and pharmacological properties prompted us to evaluate the pharmacokinetics of a new form of SAM, the phytate salt. The product was administered orally to rats and pharmacokinetic parameters were evaluated by comparing the results with that obtained by administering the SAM tosylated form (SAM PTS). It was found that phytate anion protects SAM from degradation, probably because of steric hindrance exerted by the counterion, and that the SAM phytate displayed significant better pharmacokinetic parameters compared to SAM PTS. These results open to the perspective of the use of new salts of SAM endowed with better pharmacokinetic properties.

UI MeSH Term Description Entries
D008297 Male Males
D010833 Phytic Acid Complexing agent for removal of traces of heavy metal ions. It acts also as a hypocalcemic agent. Inositol Hexaphosphate,Phytin,Calcium Phytate,Inositol Hexakisphosphate,Phytate,Sodium Phytate,Acid, Phytic,Hexakisphosphate, Inositol,Hexaphosphate, Inositol,Phytate, Calcium,Phytate, Sodium
D004355 Drug Stability The chemical and physical integrity of a pharmaceutical product. Drug Shelf Life,Drugs Shelf Lives,Shelf Life, Drugs,Drug Stabilities,Drugs Shelf Life,Drugs Shelf Live,Life, Drugs Shelf,Shelf Life, Drug,Shelf Live, Drugs,Shelf Lives, Drugs
D005260 Female Females
D000284 Administration, Oral The giving of drugs, chemicals, or other substances by mouth. Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001682 Biological Availability The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action. Availability Equivalency,Bioavailability,Physiologic Availability,Availability, Biologic,Availability, Biological,Availability, Physiologic,Biologic Availability,Availabilities, Biologic,Availabilities, Biological,Availabilities, Physiologic,Availability Equivalencies,Bioavailabilities,Biologic Availabilities,Biological Availabilities,Equivalencies, Availability,Equivalency, Availability,Physiologic Availabilities
D012436 S-Adenosylmethionine Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed) AdoMet,Ademetionine,FO-1561,Gumbaral,S Amet,S-Adenosyl-L-Methionine,S-Adenosylmethionine Sulfate Tosylate,SAM-e,Samyr,FO 1561,FO1561,S Adenosyl L Methionine,S Adenosylmethionine,S Adenosylmethionine Sulfate Tosylate
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

Antonio Francioso, and Sergio Fanelli, and Maria d'Erme, and Eugenio Lendaro, and Niccolò Miraglia, and Mario Fontana, and Rosaria A Cavallaro, and Luciana Mosca
Neuropharmacology of S-adenosyl-L-methionine.
November 1987, The American journal of medicine,
Antonio Francioso, and Sergio Fanelli, and Maria d'Erme, and Eugenio Lendaro, and Niccolò Miraglia, and Mario Fontana, and Rosaria A Cavallaro, and Luciana Mosca
Neuroendocrine effects of S-adenosyl-L-methionine, a novel putative antidepressant.
January 1990, Journal of psychiatric research,
Antonio Francioso, and Sergio Fanelli, and Maria d'Erme, and Eugenio Lendaro, and Niccolò Miraglia, and Mario Fontana, and Rosaria A Cavallaro, and Luciana Mosca
Pharmacokinetic studies of S-adenosyl-L-methionine (SAMe) in several animal species.
April 1976, Pharmacological research communications,
Antonio Francioso, and Sergio Fanelli, and Maria d'Erme, and Eugenio Lendaro, and Niccolò Miraglia, and Mario Fontana, and Rosaria A Cavallaro, and Luciana Mosca
S-Inosyl-L-Homocysteine Hydrolase, a Novel Enzyme Involved in S-Adenosyl-L-Methionine Recycling.
July 2015, Journal of bacteriology,
Antonio Francioso, and Sergio Fanelli, and Maria d'Erme, and Eugenio Lendaro, and Niccolò Miraglia, and Mario Fontana, and Rosaria A Cavallaro, and Luciana Mosca
The production of S-adenosyl-L-methionine and S-adenosyl-L-ethionine by yeast.
November 1965, Enzymologia,
Antonio Francioso, and Sergio Fanelli, and Maria d'Erme, and Eugenio Lendaro, and Niccolò Miraglia, and Mario Fontana, and Rosaria A Cavallaro, and Luciana Mosca
Chemoprevention of hepatocarcinogenesis: S-adenosyl-L-methionine.
July 2002, Alcohol (Fayetteville, N.Y.),
Antonio Francioso, and Sergio Fanelli, and Maria d'Erme, and Eugenio Lendaro, and Niccolò Miraglia, and Mario Fontana, and Rosaria A Cavallaro, and Luciana Mosca
Intestinal absorption of S-adenosyl-L-methionine.
June 1979, The Journal of pharmacology and experimental therapeutics,
Antonio Francioso, and Sergio Fanelli, and Maria d'Erme, and Eugenio Lendaro, and Niccolò Miraglia, and Mario Fontana, and Rosaria A Cavallaro, and Luciana Mosca
Using S-adenosyl-L-homocysteine capture compounds to characterize S-adenosyl-L-methionine and S-adenosyl-L-homocysteine binding proteins.
December 2014, Analytical biochemistry,
Antonio Francioso, and Sergio Fanelli, and Maria d'Erme, and Eugenio Lendaro, and Niccolò Miraglia, and Mario Fontana, and Rosaria A Cavallaro, and Luciana Mosca
S-Adenosyl-L-methionine-dependent restriction enzymes.
January 2004, Critical reviews in biochemistry and molecular biology,
Antonio Francioso, and Sergio Fanelli, and Maria d'Erme, and Eugenio Lendaro, and Niccolò Miraglia, and Mario Fontana, and Rosaria A Cavallaro, and Luciana Mosca
S-adenosyl-L-methionine and the liver.
April 1993, The Italian journal of gastroenterology,
Copied contents to your clipboard!