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To see whether the effect of cimetidine changes during a treatment period, the effect of intravenous cimetidine on pentagastrin-stimulated gastric acid and pepsin secretion was studied before and after a 6-week course of oral cimetidine treatment, 1 g/day, in 10 duodenal ulcer patients. Pentagastrin, 1.5 microgram . kg-1 . h-1, was infused for 165 min, and cimetidine, 1.2 mg . kg-1 . h-1, was added by concomitant infusion during the last 90 min. The second secretion test was carried out 60 hours after the last dose of cimetidine. Acid and pepsin secretion, in response to pentagastrin stimulation, was not significantly changed after 6 weeks of daily cimetidine treatment. The response to pentagastrin plus cimetidine was, however, significantly higher at the end than at the start of the treatment period. The results suggested a slightly reduced effect of cimetidine after prolonged use.
E Aadland, and
A Berstad
June 1978,
Agents and actions,
E Aadland, and
A Berstad
January 1973,
Scandinavian journal of gastroenterology,
E Aadland, and
A Berstad
February 1984,
Clinical pharmacology and therapeutics,
E Aadland, and
A Berstad
May 1975,
Archives internationales de physiologie et de biochimie,
E Aadland, and
A Berstad
January 1986,
Acta medica Hungarica,
E Aadland, and
A Berstad
June 1981,
Scandinavian journal of gastroenterology. Supplement,
E Aadland, and
A Berstad
December 1985,
Scandinavian journal of gastroenterology,
E Aadland, and
A Berstad
January 1983,
Zeitschrift fur Gastroenterologie,
E Aadland, and
A Berstad
September 1972,
Das Deutsche Gesundheitswesen,
E Aadland, and
A Berstad
May 1969,
The British journal of surgery,
