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We studied the effects of the intravenous or oral administration of aminohexane diphosphonate (AHDP) in 42 patients with active Paget's disease of bone. Treatment of mouth (400 mg daily for 1 month) or intravenously (25 mg or 50 mg daily for 5 days) induced marked suppression of biochemical indices of disease activity. Urinary excretion of hydroxyproline fell to 39 and 42% of pretreatment values (oral and IV treatments respectively), and was followed by a similar decrease in the serum activity of alkaline phosphatase. In both groups of patients, disease activity remained suppressed for the 6 months of followup, and pain improved in 34 out of 37 patients who had bone pain attributed to Paget's disease. Both biopsies indicated that osteoblast and osteoclast numbers decreased with no adverse effects on mineralization. Neither regime was associated with significant side effects. We conclude that short courses of AHDP provide a promising treatment for the long-term control of Paget's disease.
R M Atkins, and
A J Yates, and
R E Gray, and
G H Urwin, and
N A Hamdy, and
M N Beneton, and
S Rosini, and
J A Kanis
January 1981,
Metabolic bone disease & related research,
R M Atkins, and
A J Yates, and
R E Gray, and
G H Urwin, and
N A Hamdy, and
M N Beneton, and
S Rosini, and
J A Kanis
October 1976,
Clinical orthopaedics and related research,
R M Atkins, and
A J Yates, and
R E Gray, and
G H Urwin, and
N A Hamdy, and
M N Beneton, and
S Rosini, and
J A Kanis
January 1977,
The Journal of clinical endocrinology and metabolism,
R M Atkins, and
A J Yates, and
R E Gray, and
G H Urwin, and
N A Hamdy, and
M N Beneton, and
S Rosini, and
J A Kanis
February 1979,
Australian and New Zealand journal of medicine,
R M Atkins, and
A J Yates, and
R E Gray, and
G H Urwin, and
N A Hamdy, and
M N Beneton, and
S Rosini, and
J A Kanis
April 1973,
The Quarterly journal of medicine,
R M Atkins, and
A J Yates, and
R E Gray, and
G H Urwin, and
N A Hamdy, and
M N Beneton, and
S Rosini, and
J A Kanis
March 1976,
Lancet (London, England),
R M Atkins, and
A J Yates, and
R E Gray, and
G H Urwin, and
N A Hamdy, and
M N Beneton, and
S Rosini, and
J A Kanis
December 1981,
Schweizerische medizinische Wochenschrift,
R M Atkins, and
A J Yates, and
R E Gray, and
G H Urwin, and
N A Hamdy, and
M N Beneton, and
S Rosini, and
J A Kanis
May 1974,
The American journal of roentgenology, radium therapy, and nuclear medicine,
R M Atkins, and
A J Yates, and
R E Gray, and
G H Urwin, and
N A Hamdy, and
M N Beneton, and
S Rosini, and
J A Kanis
January 1976,
Minerva medica,
R M Atkins, and
A J Yates, and
R E Gray, and
G H Urwin, and
N A Hamdy, and
M N Beneton, and
S Rosini, and
J A Kanis
September 1979,
Lancet (London, England),
