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Elderly persons have increased morbidity and mortality due to bacterial infections. Since the polymorphonuclear leukocyte (PMN) is a major defense against bacterial infection, we utilized fluorescent microspheres and flow cytometry to examine phagocytosis by PMNs from 55 young and middle-aged adults (mean age 41.5 yrs) and two groups of elderly subjects: one group of 35 healthy individuals (mean age 74.1 years) living at home, and a second group of 11 residents (mean age 83.1 years) with severe mental and physical disabilities, living in a domiciliary care facility. We determined the percent phagocytic PMNs, the number of microspheres per PMN, and the number of microspheres per 100 PMNs. The mean number of microspheres per phagocytic PMN was similar for all groups. Statistically significant differences were found between the young and middle-aged group and the healthy or ill elderly groups for the percent phagocytic PMNs (75.3% vs 51.5% and 43.8%), and the number of microspheres per 100 phagocytic PMNs (197.3 vs 131.4 and 103.2). There were no significant differences in these parameters between healthy and debilitated elderly subjects. These data document that there is an age-related increase in representation of a population of PMNs which have a defect in phagocytic ability.
J E Nagel, and
K Han, and
P J Coon, and
W H Adler, and
B S Bender
November 1983,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
J E Nagel, and
K Han, and
P J Coon, and
W H Adler, and
B S Bender
April 1999,
Journal of periodontal research,
J E Nagel, and
K Han, and
P J Coon, and
W H Adler, and
B S Bender
February 1985,
Journal of medical microbiology,
J E Nagel, and
K Han, and
P J Coon, and
W H Adler, and
B S Bender
February 1987,
Journal of immunological methods,
J E Nagel, and
K Han, and
P J Coon, and
W H Adler, and
B S Bender
October 1968,
Science (New York, N.Y.),
J E Nagel, and
K Han, and
P J Coon, and
W H Adler, and
B S Bender
April 1981,
Infection and immunity,
J E Nagel, and
K Han, and
P J Coon, and
W H Adler, and
B S Bender
October 1983,
Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology,
J E Nagel, and
K Han, and
P J Coon, and
W H Adler, and
B S Bender
September 2002,
Current microbiology,
J E Nagel, and
K Han, and
P J Coon, and
W H Adler, and
B S Bender
July 1989,
The Journal of applied bacteriology,
J E Nagel, and
K Han, and
P J Coon, and
W H Adler, and
B S Bender
December 1984,
Journal of immunology (Baltimore, Md. : 1950),
