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Rat granulosa cells were cultured with or without PGE2 and/or PGF2 alpha. Accumulation of endogenous progesterone and 20 alpha-hydroxy-4-pregnen-3-one was determined. Additionally, [4-14C]progesterone metabolism was assessed. PGE2 increased progesterone accumulation, in part, by decreasing progesterone catabolism to 20 alpha-reduced progestins. In contrast, PGF2 alpha stimulated 20 alpha-hydroxysteroid dehydrogenase activity, thus increasing progesterone catabolism. Combined treatment with PGE2 and PGF2 alpha augmented progesterone accumulation to levels above controls but below those attained with PGE2 alone. These data indicate that PGE2 and PGF2 alpha exert opposite effects on progesterone production and catabolism and that the ratio of PGE2 to PGF2 alpha in the local granulosa cell milieu may be of importance in determining overall progesterone output.
Y S Moon, and
A J Duleba, and
K S Kim, and
B H Yuen
February 1992,
Biochimica et biophysica acta,
Y S Moon, and
A J Duleba, and
K S Kim, and
B H Yuen
August 1976,
The Journal of pharmacology and experimental therapeutics,
Y S Moon, and
A J Duleba, and
K S Kim, and
B H Yuen
July 1979,
The Indian journal of medical research,
Y S Moon, and
A J Duleba, and
K S Kim, and
B H Yuen
March 1984,
Clinical nephrology,
Y S Moon, and
A J Duleba, and
K S Kim, and
B H Yuen
December 1995,
Current eye research,
Y S Moon, and
A J Duleba, and
K S Kim, and
B H Yuen
January 1974,
Quarterly journal of experimental physiology and cognate medical sciences,
Y S Moon, and
A J Duleba, and
K S Kim, and
B H Yuen
May 1995,
Klinische Monatsblatter fur Augenheilkunde,
Y S Moon, and
A J Duleba, and
K S Kim, and
B H Yuen
March 1982,
Experientia,
Y S Moon, and
A J Duleba, and
K S Kim, and
B H Yuen
April 1996,
Digestive diseases and sciences,
Y S Moon, and
A J Duleba, and
K S Kim, and
B H Yuen
May 1988,
Digestive diseases and sciences,
