BIOMAT Database Logo BIOMAT Database Logo

Cerebellar progressive multifocal leukoencephalopathy associated with pulmonary sarcoidosis. 2021

Lajjaben Patel, and Arunmozhimaran Elavarasi, and Ajay Garg, and Aruna Nambirajan
All India Institute of Medical Sciences, New Delhi, Delhi, India.

Progressive multifocal leukoencephalopathy can complicate the course of a patient with sarcoidosis. Here we present a rare case of a 35-year-old patient with pulmonary sarcoidosis whose course was complicated by progressive multifocal leukoencephalopathy involving the cerebellum. Neuroimaging and cerebrospinal fluid PCR played a crucial role in the diagnosis.

UI MeSH Term Description Entries
D007968 Leukoencephalopathy, Progressive Multifocal An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7) Encephalitis, JC Polyomavirus,Progressive Multifocal Leukoencephalopathy,JC Polyomavirus Encephalopathy,Encephalopathies, JC Polyomavirus,Encephalopathy, JC Polyomavirus,JC Polyomavirus Encephalitis,Leukoencephalopathies, Progressive Multifocal,Multifocal Leukoencephalopathies, Progressive,Multifocal Leukoencephalopathy, Progressive,Progressive Multifocal Leukoencephalopathies
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D002531 Cerebellum The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills. Cerebella,Corpus Cerebelli,Parencephalon,Cerebellums,Parencephalons
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D017565 Sarcoidosis, Pulmonary Sarcoidosis affecting predominantly the lungs, the site most frequently involved and most commonly causing morbidity and mortality in sarcoidosis. Pulmonary sarcoidosis is characterized by sharply circumscribed granulomas in the alveolar, bronchial, and vascular walls, composed of tightly packed cells derived from the mononuclear phagocyte system. The clinical symptoms when present are dyspnea upon exertion, nonproductive cough, and wheezing. (Cecil Textbook of Medicine, 19th ed, p431) Pulmonary Sarcoidosis,Pulmonary Sarcoidoses,Sarcoidoses, Pulmonary
D059906 Neuroimaging Non-invasive methods of visualizing the CENTRAL NERVOUS SYSTEM, especially the brain, by various imaging modalities. Brain Imaging,Imaging, Brain

Related Publications

Lajjaben Patel, and Arunmozhimaran Elavarasi, and Ajay Garg, and Aruna Nambirajan
MRI Shrimp Sign in Sarcoidosis-Associated Cerebellar Progressive Multifocal Leukoencephalopathy.
February 2022, AJNR. American journal of neuroradiology,
Lajjaben Patel, and Arunmozhimaran Elavarasi, and Ajay Garg, and Aruna Nambirajan
[Progressive multifocal leukoencephalopathy and pulmonary sarcoidosis].
November 2000, Revue neurologique,
Lajjaben Patel, and Arunmozhimaran Elavarasi, and Ajay Garg, and Aruna Nambirajan
Treating sarcoidosis-associated progressive multifocal leukoencephalopathy with infliximab.
February 2022, Brain communications,
Lajjaben Patel, and Arunmozhimaran Elavarasi, and Ajay Garg, and Aruna Nambirajan
[Infratentorial progressive multifocal leukoencephalopathy in a patient with pulmonary sarcoidosis].
November 2005, RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin,
Lajjaben Patel, and Arunmozhimaran Elavarasi, and Ajay Garg, and Aruna Nambirajan
[Sarcoidosis and progressive multifocal leukoencephalopathy].
May 2001, Revue neurologique,
Lajjaben Patel, and Arunmozhimaran Elavarasi, and Ajay Garg, and Aruna Nambirajan
Progressive multifocal leukoencephalopathy in patients with sarcoidosis.
September 2014, Neurology,
Lajjaben Patel, and Arunmozhimaran Elavarasi, and Ajay Garg, and Aruna Nambirajan
Progressive multifocal leukoencephalopathy in patients with sarcoidosis.
April 2014, Neurology,
Lajjaben Patel, and Arunmozhimaran Elavarasi, and Ajay Garg, and Aruna Nambirajan
[Atypical progressive multifocal leukoencephalopathy (PML) in a patient with pulmonary sarcoidosis].
March 2010, Revue neurologique,
Lajjaben Patel, and Arunmozhimaran Elavarasi, and Ajay Garg, and Aruna Nambirajan
Cerebellar Progressive Multifocal Leukoencephalopathy Mimicking Anti-Yo-Antibody-Associated Rapidly Progressive Cerebellar Syndrome.
July 2023, Neurology international,
Lajjaben Patel, and Arunmozhimaran Elavarasi, and Ajay Garg, and Aruna Nambirajan
[Association of progressive multifocal leukoencephalopathy and sarcoidosis].
January 2016, Presse medicale (Paris, France : 1983),
Copied contents to your clipboard!