Amine-Directed Palladium-Catalyzed C-H Halogenation of Phenylalanine Derivatives. 2021

Alexia Ville, and Julien Annibaletto, and Sébastien Coufourier, and Christophe Hoarau, and Rodolphe Tamion, and Guillaume Journot, and Cédric Schneider, and Jean-François Brière
Normandie Université, UNIROUEN, INSA Rouen, CNRS, COBRA, 76000, Rouen, France.

Invited for the cover of this issue are Jean-François Brière, Cédric Schneider, Guillaume Journot and co-workers from the COBRA laboratory and Oril Industrie (Normandy, France). The image shows the progression from questioning how to easily and regioselectively introduce halogen atoms to amino acids to the discovery of a catalytic functional-group-directed C-H halogenation of phenylalanine derivatives. Read the full text of the article at 10.1002/chem.202102411.

UI MeSH Term Description Entries
D010165 Palladium A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.
D010649 Phenylalanine An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE. Endorphenyl,L-Phenylalanine,Phenylalanine, L-Isomer,L-Isomer Phenylalanine,Phenylalanine, L Isomer
D002384 Catalysis The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction. Catalyses
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000588 Amines A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed) Amine
D054879 Halogenation Covalent attachment of HALOGENS to other compounds. Bromination,Chlorination,Fluorination,Iodination,Iodation

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