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A phase II multicenter clinical study of epirubicin, a new anthracycline anticancer agent, was carried out in 46 patients with advanced breast cancer. The treatment schedule consisted of either 60 mg/m2 every three weeks or 40 to 50 mg/m2 on day 1 and day 8 every four weeks. Objective responses were observed in 23.7% of 38 evaluable patients (1 CR and 8 PR). Response rates according to previous chemotherapy were 50.0% (4/8) in previously non-treated patients and 36.4% (4/11) in patients previously treated with non-anthracyclines. The major adverse effect was bone-marrow suppression; leukopenia was observed in 82.1% of patients, anemia in 53.8% and thrombocytopenia in 20.0%. Other toxicities frequently observed were anorexia (55.0%), nausea-vomiting (55.0%) and alopecia (66.7%), but these seemed to be milder than those produced by doxorubicin.
T Tominaga, and
M Kitamura, and
Y Nomura, and
O Abe, and
K Enomoto, and
T Ikeda, and
M Izuo, and
Y Iino, and
T Taguchi, and
K Tamura
July 1986,
Gan to kagaku ryoho. Cancer & chemotherapy,
T Tominaga, and
M Kitamura, and
Y Nomura, and
O Abe, and
K Enomoto, and
T Ikeda, and
M Izuo, and
Y Iino, and
T Taguchi, and
K Tamura
August 1986,
Gan to kagaku ryoho. Cancer & chemotherapy,
T Tominaga, and
M Kitamura, and
Y Nomura, and
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K Enomoto, and
T Ikeda, and
M Izuo, and
Y Iino, and
T Taguchi, and
K Tamura
January 1987,
Anticancer research,
T Tominaga, and
M Kitamura, and
Y Nomura, and
O Abe, and
K Enomoto, and
T Ikeda, and
M Izuo, and
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T Taguchi, and
K Tamura
June 1998,
British journal of cancer,
T Tominaga, and
M Kitamura, and
Y Nomura, and
O Abe, and
K Enomoto, and
T Ikeda, and
M Izuo, and
Y Iino, and
T Taguchi, and
K Tamura
August 1991,
Anti-cancer drugs,
T Tominaga, and
M Kitamura, and
Y Nomura, and
O Abe, and
K Enomoto, and
T Ikeda, and
M Izuo, and
Y Iino, and
T Taguchi, and
K Tamura
September 1986,
Hinyokika kiyo. Acta urologica Japonica,
T Tominaga, and
M Kitamura, and
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O Abe, and
K Enomoto, and
T Ikeda, and
M Izuo, and
Y Iino, and
T Taguchi, and
K Tamura
July 2000,
Breast cancer research and treatment,
T Tominaga, and
M Kitamura, and
Y Nomura, and
O Abe, and
K Enomoto, and
T Ikeda, and
M Izuo, and
Y Iino, and
T Taguchi, and
K Tamura
October 2002,
Anti-cancer drugs,
T Tominaga, and
M Kitamura, and
Y Nomura, and
O Abe, and
K Enomoto, and
T Ikeda, and
M Izuo, and
Y Iino, and
T Taguchi, and
K Tamura
August 2000,
Annals of oncology : official journal of the European Society for Medical Oncology,
T Tominaga, and
M Kitamura, and
Y Nomura, and
O Abe, and
K Enomoto, and
T Ikeda, and
M Izuo, and
Y Iino, and
T Taguchi, and
K Tamura
July 1987,
Gan to kagaku ryoho. Cancer & chemotherapy,
