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An osteosarcoma cell line, OHS, was established from a patient with multiple skeletal manifestations of osteosarcoma, developing after bilateral retinoblastoma. The tumor cells expressed sarcoma-associated antigens and showed rapid growth in monolayers and as multicellular spheroids. They formed distinct colonies in soft agar, and subcutaneous tumors in nude mice. Morphological studies indicated that OHS cells had retained important characteristics of the cells of origin. No deletion of the retinoblastoma genes on chromosome 13q14 could be demonstrated with the banding techniques used. However, cytogenetic studies revealed double minute chromosomes, as evidence of gene amplification, as well as translocations involving chromosomes 1,6,11 and 13. The OHS line can be used to study the genetic basis of tumor initiation and growth, and to elucidate factors predisposing for second primary cancers in retinoblastoma patients.
O Fodstad, and
A Brøgger, and
O Bruland, and
O P Solheim, and
J M Nesland, and
A Pihl
August 1974,
Journal of the National Cancer Institute,
O Fodstad, and
A Brøgger, and
O Bruland, and
O P Solheim, and
J M Nesland, and
A Pihl
December 1992,
Cancer genetics and cytogenetics,
O Fodstad, and
A Brøgger, and
O Bruland, and
O P Solheim, and
J M Nesland, and
A Pihl
March 1995,
Yan ke xue bao = Eye science,
O Fodstad, and
A Brøgger, and
O Bruland, and
O P Solheim, and
J M Nesland, and
A Pihl
January 1990,
Klinische Padiatrie,
O Fodstad, and
A Brøgger, and
O Bruland, and
O P Solheim, and
J M Nesland, and
A Pihl
January 1999,
Cancer letters,
O Fodstad, and
A Brøgger, and
O Bruland, and
O P Solheim, and
J M Nesland, and
A Pihl
February 1998,
The Journal of laryngology and otology,
O Fodstad, and
A Brøgger, and
O Bruland, and
O P Solheim, and
J M Nesland, and
A Pihl
December 1983,
The Japanese journal of experimental medicine,
O Fodstad, and
A Brøgger, and
O Bruland, and
O P Solheim, and
J M Nesland, and
A Pihl
May 2000,
AJR. American journal of roentgenology,
O Fodstad, and
A Brøgger, and
O Bruland, and
O P Solheim, and
J M Nesland, and
A Pihl
October 2014,
The British journal of ophthalmology,
O Fodstad, and
A Brøgger, and
O Bruland, and
O P Solheim, and
J M Nesland, and
A Pihl
October 1990,
Clinical orthopaedics and related research,
