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Experiments were carried out on isolated rabbit hearts: PG biosynthesis was induced by administration into the coronary circulation of a single dose of arachidonic acid (100 micrograms) and the PGs synthesized and released in the heart effluent were detected by bioassays. Total flavonoids (TF) extracted from Ribes nigrum leaves and their 2 major components, rutin and isoquercitrin had neither spasmodic nor relaxing activity on rat stomach strip. They were not capable of inducing any biosynthesis and release of PG-like substances and did not act on PGE2 receptors. They inhibited both biosynthesis and release of PG-like substances: TF were more active than rutin and isoquercitrin: ID30 was 1.03 +/- 0.24 mg/ml for TF versus 3.75 +/- 0.24 mg/ml and 2.31 +/- 1.4 mg/ml for rutin and isoquercitrin respectively.
P H Chanh, and
N Ifansyah, and
R Chahine, and
A Mounayar-Chalfoun, and
J Gleye, and
C Moulis
January 1975,
Annales pharmaceutiques francaises,
P H Chanh, and
N Ifansyah, and
R Chahine, and
A Mounayar-Chalfoun, and
J Gleye, and
C Moulis
November 2013,
Phytochemistry,
P H Chanh, and
N Ifansyah, and
R Chahine, and
A Mounayar-Chalfoun, and
J Gleye, and
C Moulis
November 1988,
Prostaglandins, leukotrienes, and essential fatty acids,
P H Chanh, and
N Ifansyah, and
R Chahine, and
A Mounayar-Chalfoun, and
J Gleye, and
C Moulis
January 1986,
Journal de pharmacologie,
P H Chanh, and
N Ifansyah, and
R Chahine, and
A Mounayar-Chalfoun, and
J Gleye, and
C Moulis
January 1992,
Journal of pharmaceutical and biomedical analysis,
P H Chanh, and
N Ifansyah, and
R Chahine, and
A Mounayar-Chalfoun, and
J Gleye, and
C Moulis
October 2004,
BMC pharmacology,
P H Chanh, and
N Ifansyah, and
R Chahine, and
A Mounayar-Chalfoun, and
J Gleye, and
C Moulis
April 2016,
Food chemistry,
P H Chanh, and
N Ifansyah, and
R Chahine, and
A Mounayar-Chalfoun, and
J Gleye, and
C Moulis
December 1986,
Journal of neurochemistry,
P H Chanh, and
N Ifansyah, and
R Chahine, and
A Mounayar-Chalfoun, and
J Gleye, and
C Moulis
June 2002,
Naunyn-Schmiedeberg's archives of pharmacology,
P H Chanh, and
N Ifansyah, and
R Chahine, and
A Mounayar-Chalfoun, and
J Gleye, and
C Moulis
August 2005,
Journal of inflammation (London, England),
