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Twenty-two patients with functioning renal allografts took part in a double-blind crossover trial during which placebo, sulfamethoxazole, and trimethoprim/sulfamethoxazole were given for periods of 14 days. The patients were divided into 2 groups. The first group consisting of 12 patients had serum creatinine levels less than 0.18 mmol/L and the second group of 10 patients had serum creatinine levels between 0.18 mmol/L and 0.35 mmol/L. Renal function at the end of each period was assessed by clearance of inulin (CIn), p-aminohippurate (CPAH) and endogenous creatinine (CCr). The second group also had a pitressin concentration test as a measure of distal tubule function. There was no change in inulin or creatinine clearance or in maximum concentration after pitressin in any of the patients in any of the phases. In the first group there was an increase in PAH clearance during the sulfonamide and trimethroprim/sulfamethoxazole phases. This change was not seen in the second group of patients with significantly impaired renal function.
R J Caterson, and
P V Collett, and
V L Hood, and
G G Duggin, and
J S Horvath, and
J R Johnson, and
J Sampson, and
D J Tiller
January 2017,
Indian journal of nephrology,
R J Caterson, and
P V Collett, and
V L Hood, and
G G Duggin, and
J S Horvath, and
J R Johnson, and
J Sampson, and
D J Tiller
July 1980,
JAMA,
R J Caterson, and
P V Collett, and
V L Hood, and
G G Duggin, and
J S Horvath, and
J R Johnson, and
J Sampson, and
D J Tiller
January 2001,
Clinical nephrology,
R J Caterson, and
P V Collett, and
V L Hood, and
G G Duggin, and
J S Horvath, and
J R Johnson, and
J Sampson, and
D J Tiller
March 1993,
The Annals of pharmacotherapy,
R J Caterson, and
P V Collett, and
V L Hood, and
G G Duggin, and
J S Horvath, and
J R Johnson, and
J Sampson, and
D J Tiller
September 1998,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
R J Caterson, and
P V Collett, and
V L Hood, and
G G Duggin, and
J S Horvath, and
J R Johnson, and
J Sampson, and
D J Tiller
January 2012,
Case reports in emergency medicine,
R J Caterson, and
P V Collett, and
V L Hood, and
G G Duggin, and
J S Horvath, and
J R Johnson, and
J Sampson, and
D J Tiller
February 1984,
Lancet (London, England),
R J Caterson, and
P V Collett, and
V L Hood, and
G G Duggin, and
J S Horvath, and
J R Johnson, and
J Sampson, and
D J Tiller
January 1990,
Child nephrology and urology,
R J Caterson, and
P V Collett, and
V L Hood, and
G G Duggin, and
J S Horvath, and
J R Johnson, and
J Sampson, and
D J Tiller
September 2000,
American journal of kidney diseases : the official journal of the National Kidney Foundation,
R J Caterson, and
P V Collett, and
V L Hood, and
G G Duggin, and
J S Horvath, and
J R Johnson, and
J Sampson, and
D J Tiller
April 1973,
Annals of internal medicine,
