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Fundamental and clinical studies on imipenem/cilastatin sodium (MK-0787/MK-0791) were carried out and the results obtained were summarized below. The transfer of MK-0787/MK-0791 into female genital organ tissues was found to be satisfactory. The transfer of MK-0787/MK-0791 into umbilical arterial blood, umbilical venous blood and amniotic fluid was relatively good. A dose of 1,000 mg/1,000 mg per day of MK-0787/MK-0791 was given to each of 6 gynecology patients for 5-22 days and satisfactory clinical effect was obtained in 5 patients out of 6 patients. No notable side effects or abnormal laboratory findings were observed except for a moderate in elevation in S-GOT/S-GPT in 1 case.
T Hatase, and
K Kawano, and
R Fukagawa, and
H Hirai, and
N Ohokura, and
T Akagi, and
A Tsunawaki, and
T Kato
May 1986,
The Japanese journal of antibiotics,
T Hatase, and
K Kawano, and
R Fukagawa, and
H Hirai, and
N Ohokura, and
T Akagi, and
A Tsunawaki, and
T Kato
June 1986,
The Japanese journal of antibiotics,
T Hatase, and
K Kawano, and
R Fukagawa, and
H Hirai, and
N Ohokura, and
T Akagi, and
A Tsunawaki, and
T Kato
June 1986,
The Japanese journal of antibiotics,
T Hatase, and
K Kawano, and
R Fukagawa, and
H Hirai, and
N Ohokura, and
T Akagi, and
A Tsunawaki, and
T Kato
May 1986,
The Japanese journal of antibiotics,
T Hatase, and
K Kawano, and
R Fukagawa, and
H Hirai, and
N Ohokura, and
T Akagi, and
A Tsunawaki, and
T Kato
June 1986,
The Japanese journal of antibiotics,
T Hatase, and
K Kawano, and
R Fukagawa, and
H Hirai, and
N Ohokura, and
T Akagi, and
A Tsunawaki, and
T Kato
May 1986,
The Japanese journal of antibiotics,
T Hatase, and
K Kawano, and
R Fukagawa, and
H Hirai, and
N Ohokura, and
T Akagi, and
A Tsunawaki, and
T Kato
June 1986,
The Japanese journal of antibiotics,
T Hatase, and
K Kawano, and
R Fukagawa, and
H Hirai, and
N Ohokura, and
T Akagi, and
A Tsunawaki, and
T Kato
May 1986,
The Japanese journal of antibiotics,
T Hatase, and
K Kawano, and
R Fukagawa, and
H Hirai, and
N Ohokura, and
T Akagi, and
A Tsunawaki, and
T Kato
June 1986,
The Japanese journal of antibiotics,
T Hatase, and
K Kawano, and
R Fukagawa, and
H Hirai, and
N Ohokura, and
T Akagi, and
A Tsunawaki, and
T Kato
June 1986,
The Japanese journal of antibiotics,
