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The parathyroid hormone (PTH) analog, [Tyr34]bovine PTH-(7-34)-amide, can inhibit the PTH-mediated elevation of plasma calcium in thyroparathyroidectomized rats in vivo. The analog is devoid of PTH-like agonist activity in this system. Repeated doses of analog inhibit the animal's calcemic response to PTH. The elevation in serum calcium levels mediated by PTH in this assay reflects PTH action (calcium mobilization) on bone. Earlier studies demonstrated antagonist properties of the analog in a renal-based assay; PTH-stimulated increases in urinary phosphate and cyclic AMP excretion were completely inhibited by the synthetic analog. Along with previous studies, this report indicates that [Tyr34]bovine PTH-(7-34)-amide is an effective in vivo antagonist for several major parameters of PTH action in both kidney and bone.
S H Doppelt, and
R M Neer, and
S R Nussbaum, and
P Federico, and
J T Potts, and
M Rosenblatt
June 1990,
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
S H Doppelt, and
R M Neer, and
S R Nussbaum, and
P Federico, and
J T Potts, and
M Rosenblatt
December 1987,
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S H Doppelt, and
R M Neer, and
S R Nussbaum, and
P Federico, and
J T Potts, and
M Rosenblatt
October 1977,
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S H Doppelt, and
R M Neer, and
S R Nussbaum, and
P Federico, and
J T Potts, and
M Rosenblatt
March 1981,
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S H Doppelt, and
R M Neer, and
S R Nussbaum, and
P Federico, and
J T Potts, and
M Rosenblatt
June 1972,
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S H Doppelt, and
R M Neer, and
S R Nussbaum, and
P Federico, and
J T Potts, and
M Rosenblatt
August 1991,
Kidney international,
S H Doppelt, and
R M Neer, and
S R Nussbaum, and
P Federico, and
J T Potts, and
M Rosenblatt
July 1982,
Kidney international,
S H Doppelt, and
R M Neer, and
S R Nussbaum, and
P Federico, and
J T Potts, and
M Rosenblatt
December 1991,
Kidney international,
S H Doppelt, and
R M Neer, and
S R Nussbaum, and
P Federico, and
J T Potts, and
M Rosenblatt
November 1976,
Journal of immunology (Baltimore, Md. : 1950),
S H Doppelt, and
R M Neer, and
S R Nussbaum, and
P Federico, and
J T Potts, and
M Rosenblatt
August 1987,
The American journal of physiology,
